Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but th...

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Detalles Bibliográficos
Autores principales: Bougnères, Pierre, Valleron, Alain-Jacques
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605242/
https://www.ncbi.nlm.nih.gov/pubmed/19075294
http://dx.doi.org/10.1084/jem.20082622
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author Bougnères, Pierre
Valleron, Alain-Jacques
author_facet Bougnères, Pierre
Valleron, Alain-Jacques
author_sort Bougnères, Pierre
collection PubMed
description A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.
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spelling pubmed-26052422009-06-22 Causes of early-onset type 1 diabetes: toward data-driven environmental approaches Bougnères, Pierre Valleron, Alain-Jacques J Exp Med Commentaries A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality. The Rockefeller University Press 2008-12-22 /pmc/articles/PMC2605242/ /pubmed/19075294 http://dx.doi.org/10.1084/jem.20082622 Text en © 2008 Bougnères and Valleron This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentaries
Bougnères, Pierre
Valleron, Alain-Jacques
Causes of early-onset type 1 diabetes: toward data-driven environmental approaches
title Causes of early-onset type 1 diabetes: toward data-driven environmental approaches
title_full Causes of early-onset type 1 diabetes: toward data-driven environmental approaches
title_fullStr Causes of early-onset type 1 diabetes: toward data-driven environmental approaches
title_full_unstemmed Causes of early-onset type 1 diabetes: toward data-driven environmental approaches
title_short Causes of early-onset type 1 diabetes: toward data-driven environmental approaches
title_sort causes of early-onset type 1 diabetes: toward data-driven environmental approaches
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605242/
https://www.ncbi.nlm.nih.gov/pubmed/19075294
http://dx.doi.org/10.1084/jem.20082622
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