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Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging
AIM: To determine in vivo whether the lateral geniculate nucleus (LGN) undergoes atrophy in patients with glaucoma and vision loss compared with normal subjects. METHODS: Following institutional St Michael’s Hospital Research Ethics Board approval, a prospective and masked neuroimaging study was con...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605243/ https://www.ncbi.nlm.nih.gov/pubmed/18697810 http://dx.doi.org/10.1136/bjo.2008.138172 |
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author | Gupta, N Greenberg, G de Tilly, L Noël Gray, B Polemidiotis, M Yücel, Y H |
author_facet | Gupta, N Greenberg, G de Tilly, L Noël Gray, B Polemidiotis, M Yücel, Y H |
author_sort | Gupta, N |
collection | PubMed |
description | AIM: To determine in vivo whether the lateral geniculate nucleus (LGN) undergoes atrophy in patients with glaucoma and vision loss compared with normal subjects. METHODS: Following institutional St Michael’s Hospital Research Ethics Board approval, a prospective and masked neuroimaging study was conducted on glaucoma patients with visual-field defects affecting both eyes (n = 10) and age-matched controls (n = 8). Following informed consent, all subjects underwent 1.5-Tesla MRI. Coronal proton density magnetic resonance images of both LGNs were obtained, and LGN height measurements were measured by consensus by three neuroradiologists masked to the diagnosis. Glaucoma and control groups were compared using the t test. RESULTS: Both LGNs were identified and visualised by 1.5-Tesla MRI for every subject. Compared with controls, the mean LGN heights in glaucoma were decreased in right (4.09 (0.89) mm vs 4.74 (0.54) mm, p>0.05) and left LGNs (3.98 (0.57) mm vs 4.83 (0.95) mm; p = 0.033). The combined right and left LGN height in glaucoma was significantly decreased compared with controls (8.07 (1.06) mm vs 9.56 (0.86) mm; p = 0.005). CONCLUSION: In vivo MRI evidence of LGN degeneration in human glaucoma is consistent with ex vivo primate and human neuropathological studies. LGN atrophy may be a relevant biomarker of visual system injury and/or progression in some glaucoma patients. |
format | Text |
id | pubmed-2605243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-26052432009-01-01 Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging Gupta, N Greenberg, G de Tilly, L Noël Gray, B Polemidiotis, M Yücel, Y H Br J Ophthalmol Original Articles AIM: To determine in vivo whether the lateral geniculate nucleus (LGN) undergoes atrophy in patients with glaucoma and vision loss compared with normal subjects. METHODS: Following institutional St Michael’s Hospital Research Ethics Board approval, a prospective and masked neuroimaging study was conducted on glaucoma patients with visual-field defects affecting both eyes (n = 10) and age-matched controls (n = 8). Following informed consent, all subjects underwent 1.5-Tesla MRI. Coronal proton density magnetic resonance images of both LGNs were obtained, and LGN height measurements were measured by consensus by three neuroradiologists masked to the diagnosis. Glaucoma and control groups were compared using the t test. RESULTS: Both LGNs were identified and visualised by 1.5-Tesla MRI for every subject. Compared with controls, the mean LGN heights in glaucoma were decreased in right (4.09 (0.89) mm vs 4.74 (0.54) mm, p>0.05) and left LGNs (3.98 (0.57) mm vs 4.83 (0.95) mm; p = 0.033). The combined right and left LGN height in glaucoma was significantly decreased compared with controls (8.07 (1.06) mm vs 9.56 (0.86) mm; p = 0.005). CONCLUSION: In vivo MRI evidence of LGN degeneration in human glaucoma is consistent with ex vivo primate and human neuropathological studies. LGN atrophy may be a relevant biomarker of visual system injury and/or progression in some glaucoma patients. BMJ Publishing Group 2009-01 2008-08-12 /pmc/articles/PMC2605243/ /pubmed/18697810 http://dx.doi.org/10.1136/bjo.2008.138172 Text en © Gupta et al 2009 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Gupta, N Greenberg, G de Tilly, L Noël Gray, B Polemidiotis, M Yücel, Y H Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
title | Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
title_full | Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
title_fullStr | Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
title_full_unstemmed | Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
title_short | Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
title_sort | atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605243/ https://www.ncbi.nlm.nih.gov/pubmed/18697810 http://dx.doi.org/10.1136/bjo.2008.138172 |
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