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Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment

BACKGROUND: The Early Treatment for Retinopathy of Prematurity study (ETROP), published in 2003, established new guidelines for treatment of retinopathy of prematurity (ROP) and demonstrated improved outcomes compared to previous guidelines. We examined outcomes before and after implementing the ETR...

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Autores principales: Alme, Aaron M, Mulhern, Michael L, Hejkal, Thomas W, Meza, Jane L, Qiu, Fang, Ingvoldstad, David D, Margalit, Eyal
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605435/
https://www.ncbi.nlm.nih.gov/pubmed/19014557
http://dx.doi.org/10.1186/1471-2415-8-23
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author Alme, Aaron M
Mulhern, Michael L
Hejkal, Thomas W
Meza, Jane L
Qiu, Fang
Ingvoldstad, David D
Margalit, Eyal
author_facet Alme, Aaron M
Mulhern, Michael L
Hejkal, Thomas W
Meza, Jane L
Qiu, Fang
Ingvoldstad, David D
Margalit, Eyal
author_sort Alme, Aaron M
collection PubMed
description BACKGROUND: The Early Treatment for Retinopathy of Prematurity study (ETROP), published in 2003, established new guidelines for treatment of retinopathy of prematurity (ROP) and demonstrated improved outcomes compared to previous guidelines. We examined outcomes before and after implementing the ETROP recommendations. METHODS: A retrospective chart review was performed using records of infants who had laser ablations for ROP performed from January, 2000 through December, 2005. Data collected included date of birth; birth weight; estimated gestational age (EGA); grading of ROP; date of laser ablation; and outcome of laser surgery. Univariate association with threshold or prethreshold treatment (Pre-ETROP and Post-ETROP, respectively) were assessed using t-tests or Wilcoxon tests. Additional comparison between groups was performed using Fisher's exact tests. RESULTS: 581 patients were examined before and 464 after December 2003. Of these, 29/581 (5% – Pre-ETROP Group) and 53/464 (11% – Post-ETROP Group) patients advanced to criteria requiring laser treatment respectively (P = 0.0001). The average estimated gestational age (EGA) at birth was 26.3 and 25.2 weeks, with an average birth weight of 888 and 707 grams for Pre and Post-ETROP Groups, respectively. Stage 5 retinal detachment (RD) developed in 10.3% of eyes in the Pre-ETROP Group and 1.9% of eyes in the Post-ETROP Group (P = 0.02). CONCLUSION: After the ETROP guidelines were implemented, there was a decrease from 10.3% to 1.9% of eyes developing Stage 5 retinal detachment, despite this group having a lower average EGA and lower average birth weight. These results underscore the importance of adoption of the Revised Indications.
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spelling pubmed-26054352008-12-19 Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment Alme, Aaron M Mulhern, Michael L Hejkal, Thomas W Meza, Jane L Qiu, Fang Ingvoldstad, David D Margalit, Eyal BMC Ophthalmol Research Article BACKGROUND: The Early Treatment for Retinopathy of Prematurity study (ETROP), published in 2003, established new guidelines for treatment of retinopathy of prematurity (ROP) and demonstrated improved outcomes compared to previous guidelines. We examined outcomes before and after implementing the ETROP recommendations. METHODS: A retrospective chart review was performed using records of infants who had laser ablations for ROP performed from January, 2000 through December, 2005. Data collected included date of birth; birth weight; estimated gestational age (EGA); grading of ROP; date of laser ablation; and outcome of laser surgery. Univariate association with threshold or prethreshold treatment (Pre-ETROP and Post-ETROP, respectively) were assessed using t-tests or Wilcoxon tests. Additional comparison between groups was performed using Fisher's exact tests. RESULTS: 581 patients were examined before and 464 after December 2003. Of these, 29/581 (5% – Pre-ETROP Group) and 53/464 (11% – Post-ETROP Group) patients advanced to criteria requiring laser treatment respectively (P = 0.0001). The average estimated gestational age (EGA) at birth was 26.3 and 25.2 weeks, with an average birth weight of 888 and 707 grams for Pre and Post-ETROP Groups, respectively. Stage 5 retinal detachment (RD) developed in 10.3% of eyes in the Pre-ETROP Group and 1.9% of eyes in the Post-ETROP Group (P = 0.02). CONCLUSION: After the ETROP guidelines were implemented, there was a decrease from 10.3% to 1.9% of eyes developing Stage 5 retinal detachment, despite this group having a lower average EGA and lower average birth weight. These results underscore the importance of adoption of the Revised Indications. BioMed Central 2008-11-13 /pmc/articles/PMC2605435/ /pubmed/19014557 http://dx.doi.org/10.1186/1471-2415-8-23 Text en Copyright © 2008 Alme et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alme, Aaron M
Mulhern, Michael L
Hejkal, Thomas W
Meza, Jane L
Qiu, Fang
Ingvoldstad, David D
Margalit, Eyal
Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
title Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
title_full Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
title_fullStr Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
title_full_unstemmed Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
title_short Outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
title_sort outcome of retinopathy of prematurity patients following adoption of revised indications for treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605435/
https://www.ncbi.nlm.nih.gov/pubmed/19014557
http://dx.doi.org/10.1186/1471-2415-8-23
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