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A Naturally Occurring Mutation in ropB Suppresses SpeB Expression and Reduces M1T1 Group A Streptococcal Systemic Virulence

Epidemiological studies of group A streptococcus (GAS) have noted an inverse relationship between SpeB expression and invasive disease. However, the role of SpeB in the course of infection is still unclear. In this study we utilize a SpeB-negative M1T1 clinical isolate, 5628, with a naturally occurr...

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Detalles Bibliográficos
Autores principales:	Hollands, Andrew, Aziz, Ramy K., Kansal, Rita, Kotb, Malak, Nizet, Victor, Walker, Mark J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605554/ https://www.ncbi.nlm.nih.gov/pubmed/19116661 http://dx.doi.org/10.1371/journal.pone.0004102

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