BRCA1, Hormone, and Tissue-Specific Tumor Suppression

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the lin...

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Detalles Bibliográficos
Autor principal: Hu, Yanfen
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605575/
https://www.ncbi.nlm.nih.gov/pubmed/19119312
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author Hu, Yanfen
author_facet Hu, Yanfen
author_sort Hu, Yanfen
collection PubMed
description Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.
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spelling pubmed-26055752009-01-01 BRCA1, Hormone, and Tissue-Specific Tumor Suppression Hu, Yanfen Int J Biol Sci Review Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability. Ivyspring International Publisher 2008-12-13 /pmc/articles/PMC2605575/ /pubmed/19119312 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Hu, Yanfen
BRCA1, Hormone, and Tissue-Specific Tumor Suppression
title BRCA1, Hormone, and Tissue-Specific Tumor Suppression
title_full BRCA1, Hormone, and Tissue-Specific Tumor Suppression
title_fullStr BRCA1, Hormone, and Tissue-Specific Tumor Suppression
title_full_unstemmed BRCA1, Hormone, and Tissue-Specific Tumor Suppression
title_short BRCA1, Hormone, and Tissue-Specific Tumor Suppression
title_sort brca1, hormone, and tissue-specific tumor suppression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605575/
https://www.ncbi.nlm.nih.gov/pubmed/19119312
work_keys_str_mv AT huyanfen brca1hormoneandtissuespecifictumorsuppression

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