One-pot preparation of substituted pyrroles from α-diazocarbonyl compounds

In this work an efficient one-pot synthesis of substituted pyrroles 7a–n is described, which involves the in situ formation of dihydrofurans ethyl 5-butoxy-2-methyl-4,5-dihydrofuran-3-carboxylate (4), 1-(5-butoxy-2-methyl-4,5-dihydrofuran-3-yl)ethanone (5) and 5-butoxy-4,5-dihydrofuran-3-carbaldehyd...

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Detalles Bibliográficos
Autores principales: da Silva, Fernando de C, Fonseca, Mauricio G, Rianelli, Renata de S, Cunha, Anna C, de Souza, Maria C B V, Ferreira, Vitor F
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2008
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605617/
https://www.ncbi.nlm.nih.gov/pubmed/19104671
http://dx.doi.org/10.3762/bjoc.4.45
Descripción
Sumario:In this work an efficient one-pot synthesis of substituted pyrroles 7a–n is described, which involves the in situ formation of dihydrofurans ethyl 5-butoxy-2-methyl-4,5-dihydrofuran-3-carboxylate (4), 1-(5-butoxy-2-methyl-4,5-dihydrofuran-3-yl)ethanone (5) and 5-butoxy-4,5-dihydrofuran-3-carbaldehyde (6) followed by reaction with primary amines.

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