Chlamydia trachomatis Serology in Women with and without Ovarian Cancer

Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested....

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Detalles Bibliográficos
Autores principales: Ness, Roberta B., Shen, Caixia, Bass, Debra, Jackson, Carlynn, Moysich, Kristen, Edwards, Robert, Brunham, Robert C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605844/
https://www.ncbi.nlm.nih.gov/pubmed/19125176
http://dx.doi.org/10.1155/2008/219672
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author Ness, Roberta B.
Shen, Caixia
Bass, Debra
Jackson, Carlynn
Moysich, Kristen
Edwards, Robert
Brunham, Robert C.
author_facet Ness, Roberta B.
Shen, Caixia
Bass, Debra
Jackson, Carlynn
Moysich, Kristen
Edwards, Robert
Brunham, Robert C.
author_sort Ness, Roberta B.
collection PubMed
description Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4–0.9). These data do not support our earlier finding of elevated titers for antibodies to C. trachomatis among women with ovarian cancer.
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spelling pubmed-26058442009-01-05 Chlamydia trachomatis Serology in Women with and without Ovarian Cancer Ness, Roberta B. Shen, Caixia Bass, Debra Jackson, Carlynn Moysich, Kristen Edwards, Robert Brunham, Robert C. Infect Dis Obstet Gynecol Research Article Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4–0.9). These data do not support our earlier finding of elevated titers for antibodies to C. trachomatis among women with ovarian cancer. Hindawi Publishing Corporation 2008 2008-12-18 /pmc/articles/PMC2605844/ /pubmed/19125176 http://dx.doi.org/10.1155/2008/219672 Text en Copyright © 2008 Roberta B. Ness et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ness, Roberta B.
Shen, Caixia
Bass, Debra
Jackson, Carlynn
Moysich, Kristen
Edwards, Robert
Brunham, Robert C.
Chlamydia trachomatis Serology in Women with and without Ovarian Cancer
title Chlamydia trachomatis Serology in Women with and without Ovarian Cancer
title_full Chlamydia trachomatis Serology in Women with and without Ovarian Cancer
title_fullStr Chlamydia trachomatis Serology in Women with and without Ovarian Cancer
title_full_unstemmed Chlamydia trachomatis Serology in Women with and without Ovarian Cancer
title_short Chlamydia trachomatis Serology in Women with and without Ovarian Cancer
title_sort chlamydia trachomatis serology in women with and without ovarian cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605844/
https://www.ncbi.nlm.nih.gov/pubmed/19125176
http://dx.doi.org/10.1155/2008/219672
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