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Native R-loops Persist throughout the Mouse Mitochondrial DNA Genome

Mammalian mtDNA has been found here to harbor RNA-DNA hybrids at a variety of locations throughout the genome. The R-loop, previously characterized in vitro at the leading strand replication origin (O(H)), is isolated as a native RNA-DNA hybrid copurifying with mtDNA. Surprisingly, other mitochondri...

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Detalles Bibliográficos
Autores principales:	Brown, Timothy A., Tkachuk, Ariana N., Clayton, David A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605977/ https://www.ncbi.nlm.nih.gov/pubmed/18986989 http://dx.doi.org/10.1074/jbc.M806174200

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