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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

Lens epithelium derived growth factor (LEDGF), also known as PC4 and SFRS1 interacting protein 1 (PSIP1) and transcriptional co-activator p75, is the cellular binding partner of lentiviral integrase (IN) proteins. LEDGF accounts for the characteristic propensity of Lentivirus to integrate within act...

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Detalles Bibliográficos
Autores principales:	Hare, Stephen, Shun, Ming-Chieh, Gupta, Saumya Shree, Valkov, Eugene, Engelman, Alan, Cherepanov, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606027/ https://www.ncbi.nlm.nih.gov/pubmed/19132083 http://dx.doi.org/10.1371/journal.ppat.1000259

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