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Differential Expression of A-Type and B-Type Lamins during Hair Cycling
Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606029/ https://www.ncbi.nlm.nih.gov/pubmed/19122810 http://dx.doi.org/10.1371/journal.pone.0004114 |
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author | Hanif, Mubashir Rosengardten, Ylva Sagelius, Hanna Rozell, Björn Eriksson, Maria |
author_facet | Hanif, Mubashir Rosengardten, Ylva Sagelius, Hanna Rozell, Björn Eriksson, Maria |
author_sort | Hanif, Mubashir |
collection | PubMed |
description | Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that the lamin A/C and B proteins are expressed in skin, but little is known about their normal expression in the different skin cell-types and during the hair cycle. Our immunohistochemical staining for lamins A/C and B in wild-type mice revealed strong expression in the basal cell layer of the epidermis, the outer root sheath, and the dermal papilla during all stages of the hair cycle. Lower expression of both lamins A/C and B was seen in suprabasal cells of the epidermis, in the hypodermis, and in the bulb of catagen follicles. In addition, we have utilized a previously described mouse model of Hutchinson-Gilford progeria syndrome and show here that the expression of progerin does not result in pronounced effects on hair cycling or the expression of lamin B. |
format | Text |
id | pubmed-2606029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26060292009-01-05 Differential Expression of A-Type and B-Type Lamins during Hair Cycling Hanif, Mubashir Rosengardten, Ylva Sagelius, Hanna Rozell, Björn Eriksson, Maria PLoS One Research Article Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that the lamin A/C and B proteins are expressed in skin, but little is known about their normal expression in the different skin cell-types and during the hair cycle. Our immunohistochemical staining for lamins A/C and B in wild-type mice revealed strong expression in the basal cell layer of the epidermis, the outer root sheath, and the dermal papilla during all stages of the hair cycle. Lower expression of both lamins A/C and B was seen in suprabasal cells of the epidermis, in the hypodermis, and in the bulb of catagen follicles. In addition, we have utilized a previously described mouse model of Hutchinson-Gilford progeria syndrome and show here that the expression of progerin does not result in pronounced effects on hair cycling or the expression of lamin B. Public Library of Science 2009-01-05 /pmc/articles/PMC2606029/ /pubmed/19122810 http://dx.doi.org/10.1371/journal.pone.0004114 Text en Hanif et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hanif, Mubashir Rosengardten, Ylva Sagelius, Hanna Rozell, Björn Eriksson, Maria Differential Expression of A-Type and B-Type Lamins during Hair Cycling |
title | Differential Expression of A-Type and B-Type Lamins during Hair Cycling |
title_full | Differential Expression of A-Type and B-Type Lamins during Hair Cycling |
title_fullStr | Differential Expression of A-Type and B-Type Lamins during Hair Cycling |
title_full_unstemmed | Differential Expression of A-Type and B-Type Lamins during Hair Cycling |
title_short | Differential Expression of A-Type and B-Type Lamins during Hair Cycling |
title_sort | differential expression of a-type and b-type lamins during hair cycling |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606029/ https://www.ncbi.nlm.nih.gov/pubmed/19122810 http://dx.doi.org/10.1371/journal.pone.0004114 |
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