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Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome

OBJECTIVE—To determine whether, in accordance with observations in mouse models, high concentrations of the lipoprotein lipase inhibitors apolipoprotein (Apo) CI and ApoCIII are associated with increased triglyceride concentrations and decreased fat mass in men with the metabolic syndrome. RESEARCH...

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Autores principales: van der Ham, Rachel L.M., Dehnavi, Reza Alizadeh, Berbée, Jimmy F.P., Putter, Hein, de Roos, Albert, Romijn, Johannes A., Rensen, Patrick C.N., Tamsma, Jouke T.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606811/
https://www.ncbi.nlm.nih.gov/pubmed/18835943
http://dx.doi.org/10.2337/dc08-1330
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author van der Ham, Rachel L.M.
Dehnavi, Reza Alizadeh
Berbée, Jimmy F.P.
Putter, Hein
de Roos, Albert
Romijn, Johannes A.
Rensen, Patrick C.N.
Tamsma, Jouke T.
author_facet van der Ham, Rachel L.M.
Dehnavi, Reza Alizadeh
Berbée, Jimmy F.P.
Putter, Hein
de Roos, Albert
Romijn, Johannes A.
Rensen, Patrick C.N.
Tamsma, Jouke T.
author_sort van der Ham, Rachel L.M.
collection PubMed
description OBJECTIVE—To determine whether, in accordance with observations in mouse models, high concentrations of the lipoprotein lipase inhibitors apolipoprotein (Apo) CI and ApoCIII are associated with increased triglyceride concentrations and decreased fat mass in men with the metabolic syndrome. RESEARCH DESIGN AND METHODS—Plasma ApoCI, ApoCIII, and triglyceride concentrations were measured in the postabsorptive state in 98 men with the metabolic syndrome. Subcutaneous and visceral fat areas were measured by 3T-magnetic resonance imaging. RESULTS—Triglyceride concentrations were 49% higher, and the average visceral fat area was 26% lower (both P < 0.001), in subjects with high ApoCI and ApoCIII compared with low ApoCI and ApoCIII. Subjects with either high ApoCI or ApoCIII had 16% (P < 0.05) and 18% (P < 0.01) decreased visceral fat area, respectively. CONCLUSIONS—High concentrations of ApoCI and ApoCIII are associated with increased triglycerides and decreased visceral fat mass in men with the metabolic syndrome. These findings translate mouse studies into human pathophysiology.
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spelling pubmed-26068112010-01-01 Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome van der Ham, Rachel L.M. Dehnavi, Reza Alizadeh Berbée, Jimmy F.P. Putter, Hein de Roos, Albert Romijn, Johannes A. Rensen, Patrick C.N. Tamsma, Jouke T. Diabetes Care Cardiovascular and Metabolic Risk OBJECTIVE—To determine whether, in accordance with observations in mouse models, high concentrations of the lipoprotein lipase inhibitors apolipoprotein (Apo) CI and ApoCIII are associated with increased triglyceride concentrations and decreased fat mass in men with the metabolic syndrome. RESEARCH DESIGN AND METHODS—Plasma ApoCI, ApoCIII, and triglyceride concentrations were measured in the postabsorptive state in 98 men with the metabolic syndrome. Subcutaneous and visceral fat areas were measured by 3T-magnetic resonance imaging. RESULTS—Triglyceride concentrations were 49% higher, and the average visceral fat area was 26% lower (both P < 0.001), in subjects with high ApoCI and ApoCIII compared with low ApoCI and ApoCIII. Subjects with either high ApoCI or ApoCIII had 16% (P < 0.05) and 18% (P < 0.01) decreased visceral fat area, respectively. CONCLUSIONS—High concentrations of ApoCI and ApoCIII are associated with increased triglycerides and decreased visceral fat mass in men with the metabolic syndrome. These findings translate mouse studies into human pathophysiology. American Diabetes Association 2009-01 /pmc/articles/PMC2606811/ /pubmed/18835943 http://dx.doi.org/10.2337/dc08-1330 Text en Copyright © 2009, American Diabetes Association https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Cardiovascular and Metabolic Risk
van der Ham, Rachel L.M.
Dehnavi, Reza Alizadeh
Berbée, Jimmy F.P.
Putter, Hein
de Roos, Albert
Romijn, Johannes A.
Rensen, Patrick C.N.
Tamsma, Jouke T.
Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
title Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
title_full Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
title_fullStr Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
title_full_unstemmed Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
title_short Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
title_sort plasma apolipoprotein ci and ciii levels are associated with increased plasma triglyceride levels and decreased fat mass in men with the metabolic syndrome
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606811/
https://www.ncbi.nlm.nih.gov/pubmed/18835943
http://dx.doi.org/10.2337/dc08-1330
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