Cargando…

Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes

OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-section...

Descripción completa

Detalles Bibliográficos
Autores principales: Thorn, Lena M., Forsblom, Carol, Wadén, Johan, Söderlund, Jenny, Rosengård-Bärlund, Milla, Saraheimo, Markku, Heikkilä, Outi, Hietala, Kustaa, Pettersson-Fernholm, Kim, Ilonen, Jorma, Groop, Per-Henrik
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606832/
https://www.ncbi.nlm.nih.gov/pubmed/18835950
http://dx.doi.org/10.2337/dc08-0472
_version_ 1782162991577300992
author Thorn, Lena M.
Forsblom, Carol
Wadén, Johan
Söderlund, Jenny
Rosengård-Bärlund, Milla
Saraheimo, Markku
Heikkilä, Outi
Hietala, Kustaa
Pettersson-Fernholm, Kim
Ilonen, Jorma
Groop, Per-Henrik
author_facet Thorn, Lena M.
Forsblom, Carol
Wadén, Johan
Söderlund, Jenny
Rosengård-Bärlund, Milla
Saraheimo, Markku
Heikkilä, Outi
Hietala, Kustaa
Pettersson-Fernholm, Kim
Ilonen, Jorma
Groop, Per-Henrik
author_sort Thorn, Lena M.
collection PubMed
description OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-sectional study design in 1,860 patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study (620 patients with and 1,240 age-matched patients without a parental history of type 2 diabetes). Information on parental history was received from the type 1 diabetic offspring by a standardized questionnaire. RESULTS—Patients with type 1 diabetes and a positive parental history of type 2 diabetes had a higher prevalence of the metabolic syndrome (44 vs. 38%; P = 0.013) and a metabolic profile related to insulin resistance (higher BMI, larger waist circumference, and higher triglycerides, A1C, and insulin dose per kilogram) and also had a later onset of type 1 diabetes (17.2 ± 9.2 vs. 16.1 ± 8.9 years; P = 0.008), which was also confirmed in the publicly available Diabetes Control and Complications Trial data set. In contrast, no association was observed with blood pressure, diabetes complications, or HLA genotype distribution. Parental history of type 2 diabetes was independently associated with age at onset of type 1 diabetes (odds ratio 1.02 [95% CI 1.01–1.03]), BMI (1.07 [1.02–1.12]), triglycerides (1.18 [1.03–1.35]), and insulin dose per kilogram (1.63 [1.04–2.54]). CONCLUSIONS—Parental history of type 2 diabetes is associated with a later onset of type 1 diabetes, the metabolic syndrome, and a metabolic profile related to insulin resistance.
format Text
id pubmed-2606832
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-26068322010-01-01 Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes Thorn, Lena M. Forsblom, Carol Wadén, Johan Söderlund, Jenny Rosengård-Bärlund, Milla Saraheimo, Markku Heikkilä, Outi Hietala, Kustaa Pettersson-Fernholm, Kim Ilonen, Jorma Groop, Per-Henrik Diabetes Care Epidemiology/Health Services Research OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-sectional study design in 1,860 patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study (620 patients with and 1,240 age-matched patients without a parental history of type 2 diabetes). Information on parental history was received from the type 1 diabetic offspring by a standardized questionnaire. RESULTS—Patients with type 1 diabetes and a positive parental history of type 2 diabetes had a higher prevalence of the metabolic syndrome (44 vs. 38%; P = 0.013) and a metabolic profile related to insulin resistance (higher BMI, larger waist circumference, and higher triglycerides, A1C, and insulin dose per kilogram) and also had a later onset of type 1 diabetes (17.2 ± 9.2 vs. 16.1 ± 8.9 years; P = 0.008), which was also confirmed in the publicly available Diabetes Control and Complications Trial data set. In contrast, no association was observed with blood pressure, diabetes complications, or HLA genotype distribution. Parental history of type 2 diabetes was independently associated with age at onset of type 1 diabetes (odds ratio 1.02 [95% CI 1.01–1.03]), BMI (1.07 [1.02–1.12]), triglycerides (1.18 [1.03–1.35]), and insulin dose per kilogram (1.63 [1.04–2.54]). CONCLUSIONS—Parental history of type 2 diabetes is associated with a later onset of type 1 diabetes, the metabolic syndrome, and a metabolic profile related to insulin resistance. American Diabetes Association 2009-01 /pmc/articles/PMC2606832/ /pubmed/18835950 http://dx.doi.org/10.2337/dc08-0472 Text en Copyright © 2009, American Diabetes Association https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Epidemiology/Health Services Research
Thorn, Lena M.
Forsblom, Carol
Wadén, Johan
Söderlund, Jenny
Rosengård-Bärlund, Milla
Saraheimo, Markku
Heikkilä, Outi
Hietala, Kustaa
Pettersson-Fernholm, Kim
Ilonen, Jorma
Groop, Per-Henrik
Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
title Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
title_full Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
title_fullStr Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
title_full_unstemmed Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
title_short Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
title_sort effect of parental type 2 diabetes on offspring with type 1 diabetes
topic Epidemiology/Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606832/
https://www.ncbi.nlm.nih.gov/pubmed/18835950
http://dx.doi.org/10.2337/dc08-0472
work_keys_str_mv AT thornlenam effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT forsblomcarol effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT wadenjohan effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT soderlundjenny effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT rosengardbarlundmilla effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT saraheimomarkku effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT heikkilaouti effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT hietalakustaa effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT petterssonfernholmkim effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT ilonenjorma effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT groopperhenrik effectofparentaltype2diabetesonoffspringwithtype1diabetes
AT effectofparentaltype2diabetesonoffspringwithtype1diabetes