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Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-section...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606832/ https://www.ncbi.nlm.nih.gov/pubmed/18835950 http://dx.doi.org/10.2337/dc08-0472 |
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author | Thorn, Lena M. Forsblom, Carol Wadén, Johan Söderlund, Jenny Rosengård-Bärlund, Milla Saraheimo, Markku Heikkilä, Outi Hietala, Kustaa Pettersson-Fernholm, Kim Ilonen, Jorma Groop, Per-Henrik |
author_facet | Thorn, Lena M. Forsblom, Carol Wadén, Johan Söderlund, Jenny Rosengård-Bärlund, Milla Saraheimo, Markku Heikkilä, Outi Hietala, Kustaa Pettersson-Fernholm, Kim Ilonen, Jorma Groop, Per-Henrik |
author_sort | Thorn, Lena M. |
collection | PubMed |
description | OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-sectional study design in 1,860 patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study (620 patients with and 1,240 age-matched patients without a parental history of type 2 diabetes). Information on parental history was received from the type 1 diabetic offspring by a standardized questionnaire. RESULTS—Patients with type 1 diabetes and a positive parental history of type 2 diabetes had a higher prevalence of the metabolic syndrome (44 vs. 38%; P = 0.013) and a metabolic profile related to insulin resistance (higher BMI, larger waist circumference, and higher triglycerides, A1C, and insulin dose per kilogram) and also had a later onset of type 1 diabetes (17.2 ± 9.2 vs. 16.1 ± 8.9 years; P = 0.008), which was also confirmed in the publicly available Diabetes Control and Complications Trial data set. In contrast, no association was observed with blood pressure, diabetes complications, or HLA genotype distribution. Parental history of type 2 diabetes was independently associated with age at onset of type 1 diabetes (odds ratio 1.02 [95% CI 1.01–1.03]), BMI (1.07 [1.02–1.12]), triglycerides (1.18 [1.03–1.35]), and insulin dose per kilogram (1.63 [1.04–2.54]). CONCLUSIONS—Parental history of type 2 diabetes is associated with a later onset of type 1 diabetes, the metabolic syndrome, and a metabolic profile related to insulin resistance. |
format | Text |
id | pubmed-2606832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-26068322010-01-01 Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes Thorn, Lena M. Forsblom, Carol Wadén, Johan Söderlund, Jenny Rosengård-Bärlund, Milla Saraheimo, Markku Heikkilä, Outi Hietala, Kustaa Pettersson-Fernholm, Kim Ilonen, Jorma Groop, Per-Henrik Diabetes Care Epidemiology/Health Services Research OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-sectional study design in 1,860 patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study (620 patients with and 1,240 age-matched patients without a parental history of type 2 diabetes). Information on parental history was received from the type 1 diabetic offspring by a standardized questionnaire. RESULTS—Patients with type 1 diabetes and a positive parental history of type 2 diabetes had a higher prevalence of the metabolic syndrome (44 vs. 38%; P = 0.013) and a metabolic profile related to insulin resistance (higher BMI, larger waist circumference, and higher triglycerides, A1C, and insulin dose per kilogram) and also had a later onset of type 1 diabetes (17.2 ± 9.2 vs. 16.1 ± 8.9 years; P = 0.008), which was also confirmed in the publicly available Diabetes Control and Complications Trial data set. In contrast, no association was observed with blood pressure, diabetes complications, or HLA genotype distribution. Parental history of type 2 diabetes was independently associated with age at onset of type 1 diabetes (odds ratio 1.02 [95% CI 1.01–1.03]), BMI (1.07 [1.02–1.12]), triglycerides (1.18 [1.03–1.35]), and insulin dose per kilogram (1.63 [1.04–2.54]). CONCLUSIONS—Parental history of type 2 diabetes is associated with a later onset of type 1 diabetes, the metabolic syndrome, and a metabolic profile related to insulin resistance. American Diabetes Association 2009-01 /pmc/articles/PMC2606832/ /pubmed/18835950 http://dx.doi.org/10.2337/dc08-0472 Text en Copyright © 2009, American Diabetes Association https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Epidemiology/Health Services Research Thorn, Lena M. Forsblom, Carol Wadén, Johan Söderlund, Jenny Rosengård-Bärlund, Milla Saraheimo, Markku Heikkilä, Outi Hietala, Kustaa Pettersson-Fernholm, Kim Ilonen, Jorma Groop, Per-Henrik Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes |
title | Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
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title_full | Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
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title_fullStr | Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
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title_full_unstemmed | Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
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title_short | Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
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title_sort | effect of parental type 2 diabetes on offspring with type 1 diabetes |
topic | Epidemiology/Health Services Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606832/ https://www.ncbi.nlm.nih.gov/pubmed/18835950 http://dx.doi.org/10.2337/dc08-0472 |
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