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Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β

OBJECTIVE—There is evidence that insulin reduces brain injury evoked by ischemia/reperfusion (I/R). However, the molecular mechanisms underlying the protective effects of insulin remain unknown. Insulin is a well-known inhibitor of glycogen synthase kinase-3β (GSK-3β). Here, we investigate the role...

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Detalles Bibliográficos
Autores principales:	Collino, Massimo, Aragno, Manuela, Castiglia, Sara, Tomasinelli, Chiara, Thiemermann, Christoph, Boccuzzi, Giuseppe, Fantozzi, Roberto
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Pharmacology & Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606878/ https://www.ncbi.nlm.nih.gov/pubmed/18840784 http://dx.doi.org/10.2337/db08-0691

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