UBF levels determine the number of active ribosomal RNA genes in mammals

In mammals, the mechanisms regulating the number of active copies of the ∼200 ribosomal RNA (rRNA) genes transcribed by RNA polymerase I are unclear. We demonstrate that depletion of the transcription factor upstream binding factor (UBF) leads to the stable and reversible methylation-independent sil...

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Detalles Bibliográficos
Autores principales: Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Quin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606969/
https://www.ncbi.nlm.nih.gov/pubmed/19103806
http://dx.doi.org/10.1083/jcb.200805146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606969/
https://www.ncbi.nlm.nih.gov/pubmed/19103806
http://dx.doi.org/10.1083/jcb.200805146

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