Cargando…

UBF levels determine the number of active ribosomal RNA genes in mammals

In mammals, the mechanisms regulating the number of active copies of the ∼200 ribosomal RNA (rRNA) genes transcribed by RNA polymerase I are unclear. We demonstrate that depletion of the transcription factor upstream binding factor (UBF) leads to the stable and reversible methylation-independent sil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Quin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606969/ https://www.ncbi.nlm.nih.gov/pubmed/19103806 http://dx.doi.org/10.1083/jcb.200805146

Ejemplares similares

Genome wide mapping of UBF binding-sites in mouse and human cell lines
por: Diesch, Jeannine, et al.
Publicado: (2015)

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation
por: Poortinga, Gretchen, et al.
Publicado: (2011)

The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
por: Stefanovsky, Victor Y., et al.
Publicado: (2008)

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
por: Kusnadi, Eric P, et al.
Publicado: (2020)

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
por: Diesch, Jeannine, et al.
Publicado: (2014)

A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription
por: Herdman, Chelsea, et al.
Publicado: (2017)

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer
por: Yan, Shunfei, et al.
Publicado: (2017)

Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells
por: Hamdane, Nourdine, et al.
Publicado: (2015)

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
por: Quin, Jaclyn, et al.
Publicado: (2016)

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461
por: Son, Jinbae, et al.
Publicado: (2020)

Conditional Inactivation of Upstream Binding Factor Reveals Its Epigenetic Functions and the Existence of a Somatic Nucleolar Precursor Body
por: Hamdane, Nourdine, et al.
Publicado: (2014)

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes
por: Sanij, Elaine, et al.
Publicado: (2015)

Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I
por: Meraner, Joachim, et al.
Publicado: (2006)

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
por: Diesch, Jeannine, et al.
Publicado: (2019)

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
por: Kerry, Louise E., et al.
Publicado: (2017)

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription
por: Kang, Jian, et al.
Publicado: (2016)

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
por: Kang, Jian, et al.
Publicado: (2021)

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers
por: Udugama, Maheshi, et al.
Publicado: (2018)

The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation
por: Lessard, Frédéric, et al.
Publicado: (2012)

The Ribosomal Gene Loci—The Power behind the Throne
por: Panov, Konstantin I., et al.
Publicado: (2021)

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis
por: Lafita-Navarro, Maria del Carmen, et al.
Publicado: (2016)

Transcription factor UBF depletion in mouse cells results in downregulation of both downstream and upstream elements of the rRNA transcription network
por: Theophanous, Andria, et al.
Publicado: (2023)

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
por: Sanij, Elaine, et al.
Publicado: (2020)

CK2-mediated stimulation of Pol I transcription by stabilization of UBF–SL1 interaction
por: Lin, Chih-Yin, et al.
Publicado: (2006)

HP1β-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs
por: Stixová, Lenka, et al.
Publicado: (2014)

The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity
por: Azuara-Medina, Paulina Margarita, et al.
Publicado: (2019)

ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription
por: Hwang, Yu Jin, et al.
Publicado: (2014)

Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor
Publicado: (1991)

A functional genetic screen defines the AKT-induced senescence signaling network
por: Chan, Keefe T., et al.
Publicado: (2019)

UBF complexes with phosphatidylinositol 4,5-bisphosphate in nucleolar organizer regions regardless of ongoing RNA polymerase I activity
por: Sobol, Margarita, et al.
Publicado: (2013)

CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer
por: Xuan, Jiachen, et al.
Publicado: (2020)

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer
por: Yan, Shunfei, et al.
Publicado: (2020)

MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals
por: Wredenberg, Anna, et al.
Publicado: (2013)

Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA
por: Shirokikh, Nikolay E., et al.
Publicado: (2019)

Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome
por: Tremblay, Michel G., et al.
Publicado: (2022)

In vivo evidence that TATA-binding protein/SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive
Publicado: (1996)

The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF
por: Rajput, Pallavi, et al.
Publicado: (2015)

hALP, A Novel Transcriptional U Three Protein (t-UTP), Activates RNA Polymerase I Transcription by Binding and Acetylating the Upstream Binding Factor (UBF)
por: Kong, Ruirui, et al.
Publicado: (2011)

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells
por: Diesch, Jeannine, et al.
Publicado: (2014)

Too much or too little: Harnessing senescence to control oncogene-driven cancer
por: Hannan, Katherine M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8armhpkdtvf7eebroenmcu5qoh