Dilated Cardiomyopathy with Increased SR Ca(2+) Loading Preceded by a Hypercontractile State and Diastolic Failure in the α(1C)TG Mouse

Mice over-expressing the α(1−)subunit (pore) of the L-type Ca(2+) channel (α(1C)TG) by 4months (mo) of age exhibit an enlarged heart, hypertrophied myocytes, increased Ca(2+) current and Ca(2+) transient amplitude, but a normal SR Ca(2+) load. With advancing age (8–11 mo), some mice demonstrate adva...

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Detalles Bibliográficos
Autores principales: Wang, Su, Ziman, Bruce, Bodi, Ilona, Rubio, Marta, Zhou, Ying-Ying, D'Souza, Karen, Bishopric, Nanette H., Schwartz, Arnold, Lakatta, Edward G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607013/
https://www.ncbi.nlm.nih.gov/pubmed/19125184
http://dx.doi.org/10.1371/journal.pone.0004133

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