The role of conserved residues of chagasin in the inhibition of cysteine peptidases

We have evaluated the roles of key amino acids to the action of the natural inhibitor chagasin of papain-family cysteine peptidases. A W93A substitution decreased inhibitor affinity for human cathepsin L 100-fold, while substitutions of T31 resulted in 10–100-fold increases in the K(i) for cruzipain...

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Detalles Bibliográficos
Autores principales: dos Reis, Flavia C.G., Smith, Brian O., Santos, Camila C., Costa, Tatiana, F.R., Scharfstein, Julio, Coombs, Graham H., Mottram, Jeremy C., Lima, Ana Paula C.A.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607524/
https://www.ncbi.nlm.nih.gov/pubmed/18201565
http://dx.doi.org/10.1016/j.febslet.2008.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607524/
https://www.ncbi.nlm.nih.gov/pubmed/18201565
http://dx.doi.org/10.1016/j.febslet.2008.01.008

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