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The role of conserved residues of chagasin in the inhibition of cysteine peptidases
We have evaluated the roles of key amino acids to the action of the natural inhibitor chagasin of papain-family cysteine peptidases. A W93A substitution decreased inhibitor affinity for human cathepsin L 100-fold, while substitutions of T31 resulted in 10–100-fold increases in the K(i) for cruzipain...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607524/ https://www.ncbi.nlm.nih.gov/pubmed/18201565 http://dx.doi.org/10.1016/j.febslet.2008.01.008 |