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Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature
In malignant gliomas, the integrin adhesion receptors seem to play a key role for invasive growth and angiogenesis. However, there is still a controversy about the expression and the distribution of α(v)β(3) integrin caused by malignancy. The aim of our study was to assess the extent and pattern of...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Blackwell Publishing Ltd
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607528/ https://www.ncbi.nlm.nih.gov/pubmed/18394009 http://dx.doi.org/10.1111/j.1750-3639.2008.00137.x |
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author | Schnell, Oliver Krebs, Bjarne Wagner, Erika Romagna, Alexander Beer, Ambros J. Grau, Stefan J. Thon, Niklas Goetz, Claudia Kretzschmar, Hans A. Tonn, Jörg‐Christian Goldbrunner, Roland H. |
author_facet | Schnell, Oliver Krebs, Bjarne Wagner, Erika Romagna, Alexander Beer, Ambros J. Grau, Stefan J. Thon, Niklas Goetz, Claudia Kretzschmar, Hans A. Tonn, Jörg‐Christian Goldbrunner, Roland H. |
author_sort | Schnell, Oliver |
collection | PubMed |
description | In malignant gliomas, the integrin adhesion receptors seem to play a key role for invasive growth and angiogenesis. However, there is still a controversy about the expression and the distribution of α(v)β(3) integrin caused by malignancy. The aim of our study was to assess the extent and pattern of α(v)β(3) integrin expression within primary glioblastomas (GBMs) compared with low‐grade gliomas (LGGs). Tumor samples were immunostained for the detection of α(v)β(3) integrin and quantified by an imaging software. The expression of α(v)β(3) was found to be significantly higher in GBMs than in LGGs, whereby focal strong reactivity was restricted to GBMs only. Subsequent analysis revealed that not only endothelial cells but also, to a large extent, glial tumor cells contribute to the overall amount of α(v)β(3) integrin in the tumors. To further analyze the integrin subunits, Western blots from histologic sections were performed, which demonstrated a significant difference in the expression of the β(3) integrin subunit between GBMs and LGGs. The presented data lead to new insights in the pattern of α(v)β(3) integrin in gliomas and are of relevance for the inhibition of α(v)β(3) integrin with specific RGD peptides and interfering drugs to reduce angiogenesis and tumor growth. |
format | Text |
id | pubmed-2607528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-26075282008-12-29 Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature Schnell, Oliver Krebs, Bjarne Wagner, Erika Romagna, Alexander Beer, Ambros J. Grau, Stefan J. Thon, Niklas Goetz, Claudia Kretzschmar, Hans A. Tonn, Jörg‐Christian Goldbrunner, Roland H. Brain Pathol Research Articles In malignant gliomas, the integrin adhesion receptors seem to play a key role for invasive growth and angiogenesis. However, there is still a controversy about the expression and the distribution of α(v)β(3) integrin caused by malignancy. The aim of our study was to assess the extent and pattern of α(v)β(3) integrin expression within primary glioblastomas (GBMs) compared with low‐grade gliomas (LGGs). Tumor samples were immunostained for the detection of α(v)β(3) integrin and quantified by an imaging software. The expression of α(v)β(3) was found to be significantly higher in GBMs than in LGGs, whereby focal strong reactivity was restricted to GBMs only. Subsequent analysis revealed that not only endothelial cells but also, to a large extent, glial tumor cells contribute to the overall amount of α(v)β(3) integrin in the tumors. To further analyze the integrin subunits, Western blots from histologic sections were performed, which demonstrated a significant difference in the expression of the β(3) integrin subunit between GBMs and LGGs. The presented data lead to new insights in the pattern of α(v)β(3) integrin in gliomas and are of relevance for the inhibition of α(v)β(3) integrin with specific RGD peptides and interfering drugs to reduce angiogenesis and tumor growth. Blackwell Publishing Ltd 2008-04-03 /pmc/articles/PMC2607528/ /pubmed/18394009 http://dx.doi.org/10.1111/j.1750-3639.2008.00137.x Text en © 2008 The Authors. Journal Compilation © 2008 International Society of Neuropathology Open access. |
spellingShingle | Research Articles Schnell, Oliver Krebs, Bjarne Wagner, Erika Romagna, Alexander Beer, Ambros J. Grau, Stefan J. Thon, Niklas Goetz, Claudia Kretzschmar, Hans A. Tonn, Jörg‐Christian Goldbrunner, Roland H. Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature |
title | Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature |
title_full | Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature |
title_fullStr | Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature |
title_full_unstemmed | Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature |
title_short | Expression of Integrin α(v)β(3) in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature |
title_sort | expression of integrin α(v)β(3) in gliomas correlates with tumor grade and is not restricted to tumor vasculature |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607528/ https://www.ncbi.nlm.nih.gov/pubmed/18394009 http://dx.doi.org/10.1111/j.1750-3639.2008.00137.x |
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