Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia

We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004–2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate–mefloquine therapy failures occu...

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Autores principales: Shah, Naman K., Alker, Alisa P., Sem, Rithy, Susanti, Agustina Ika, Muth, Sinuon, Maguire, Jason D., Duong, Socheat, Ariey, Frederic, Meshnick, Steven R., Wongsrichanalai, Chansuda
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2008
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2609877/
https://www.ncbi.nlm.nih.gov/pubmed/18826834
http://dx.doi.org/10.3201/eid1410.080080
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author Shah, Naman K.
Alker, Alisa P.
Sem, Rithy
Susanti, Agustina Ika
Muth, Sinuon
Maguire, Jason D.
Duong, Socheat
Ariey, Frederic
Meshnick, Steven R.
Wongsrichanalai, Chansuda
author_facet Shah, Naman K.
Alker, Alisa P.
Sem, Rithy
Susanti, Agustina Ika
Muth, Sinuon
Maguire, Jason D.
Duong, Socheat
Ariey, Frederic
Meshnick, Steven R.
Wongsrichanalai, Chansuda
author_sort Shah, Naman K.
collection PubMed
description We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004–2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate–mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.
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spelling pubmed-26098772009-01-13 Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia Shah, Naman K. Alker, Alisa P. Sem, Rithy Susanti, Agustina Ika Muth, Sinuon Maguire, Jason D. Duong, Socheat Ariey, Frederic Meshnick, Steven R. Wongsrichanalai, Chansuda Emerg Infect Dis Dispatch We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004–2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate–mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective. Centers for Disease Control and Prevention 2008-10 /pmc/articles/PMC2609877/ /pubmed/18826834 http://dx.doi.org/10.3201/eid1410.080080 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Shah, Naman K.
Alker, Alisa P.
Sem, Rithy
Susanti, Agustina Ika
Muth, Sinuon
Maguire, Jason D.
Duong, Socheat
Ariey, Frederic
Meshnick, Steven R.
Wongsrichanalai, Chansuda
Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia
title Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia
title_full Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia
title_fullStr Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia
title_full_unstemmed Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia
title_short Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia
title_sort molecular surveillance for multidrug-resistant plasmodium falciparum, cambodia
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2609877/
https://www.ncbi.nlm.nih.gov/pubmed/18826834
http://dx.doi.org/10.3201/eid1410.080080
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