HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi

The activity and level of HMG-CoA reductase (HMGR) were addressed in halophilic fungi isolated from solar saltpans. Representative fungi belonging to the orders Dothideales, Eurotiales and Wallemiales have a specific pattern of HMGR regulation, which differs from salt-sensitive and moderately salt-t...

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Autores principales: Vaupotič, T., Veranic, P., Petrovič, U., Gunde-Cimerman, N., Plemenitaš, A.
Formato: Texto
Lenguaje:English
Publicado: CBS Fungal Biodiversity Centre 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610301/
https://www.ncbi.nlm.nih.gov/pubmed/19287527
http://dx.doi.org/10.3114/sim.2008.61.05
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author Vaupotič, T.
Veranic, P.
Petrovič, U.
Gunde-Cimerman, N.
Plemenitaš, A.
author_facet Vaupotič, T.
Veranic, P.
Petrovič, U.
Gunde-Cimerman, N.
Plemenitaš, A.
author_sort Vaupotič, T.
collection PubMed
description The activity and level of HMG-CoA reductase (HMGR) were addressed in halophilic fungi isolated from solar saltpans. Representative fungi belonging to the orders Dothideales, Eurotiales and Wallemiales have a specific pattern of HMGR regulation, which differs from salt-sensitive and moderately salt-tolerant yeasts. In all of the halophilic fungi studied, HMGR amounts and activities were the lowest at optimal growth salinity and increased under hyposaline and hypersaline conditions. This profile paralleled isoprenylation of cellular proteins in H. werneckii. Inhibition of HMGR in vivo by lovastatin impaired the halotolerant character. HMGR may thus serve as an important molecular marker of halotolerance.
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spelling pubmed-26103012009-03-13 HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi Vaupotič, T. Veranic, P. Petrovič, U. Gunde-Cimerman, N. Plemenitaš, A. Stud Mycol Articles The activity and level of HMG-CoA reductase (HMGR) were addressed in halophilic fungi isolated from solar saltpans. Representative fungi belonging to the orders Dothideales, Eurotiales and Wallemiales have a specific pattern of HMGR regulation, which differs from salt-sensitive and moderately salt-tolerant yeasts. In all of the halophilic fungi studied, HMGR amounts and activities were the lowest at optimal growth salinity and increased under hyposaline and hypersaline conditions. This profile paralleled isoprenylation of cellular proteins in H. werneckii. Inhibition of HMGR in vivo by lovastatin impaired the halotolerant character. HMGR may thus serve as an important molecular marker of halotolerance. CBS Fungal Biodiversity Centre 2008 /pmc/articles/PMC2610301/ /pubmed/19287527 http://dx.doi.org/10.3114/sim.2008.61.05 Text en Copyright © Copyright 2008 CBS Fungal Biodiversity Centre You are free to share - to copy, distribute and transmit the work, under the following conditions: Attribution:  You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work). Non-commercial:  You may not use this work for commercial purposes. No derivative works:  You may not alter, transform, or build upon this work. For any reuse or distribution, you must make clear to others the license terms of this work, which can be found at http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode. (http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode) Any of the above conditions can be waived if you get permission from the copyright holder. Nothing in this license impairs or restricts the author's moral rights.
spellingShingle Articles
Vaupotič, T.
Veranic, P.
Petrovič, U.
Gunde-Cimerman, N.
Plemenitaš, A.
HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
title HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
title_full HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
title_fullStr HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
title_full_unstemmed HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
title_short HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
title_sort hmg-coa reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610301/
https://www.ncbi.nlm.nih.gov/pubmed/19287527
http://dx.doi.org/10.3114/sim.2008.61.05
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