Cargando…

Statins Activate Human PPARα Promoter and Increase PPARα mRNA Expression and Activation in HepG2 Cells

Statins increase peroxisome proliferator-activated receptor α (PPARα) mRNA expression, but the mechanism of this increased PPARα production remains elusive. To examine the regulation of PPARα production, we examined the effect of 7 statins (atorvastatin, cerivastatin, fluvastatin, pitavastatin, prav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seo, Makoto, Inoue, Ikuo, Ikeda, Masaaki, Nakano, Takanari, Takahashi, Seiichiro, Katayama, Shigehiro, Komoda, Tsugikazu
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610383/ https://www.ncbi.nlm.nih.gov/pubmed/19125197 http://dx.doi.org/10.1155/2008/316306

Ejemplares similares

Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXR [Formula: see text]-Regulated and CLOCK/BMAL1-Regulated Systems
por: Nakamura, Koh-ichi, et al.
Publicado: (2008)

A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-γ (Pparγ1sv) Cooperatively Regulates Adipocyte Differentiation with Pparγ2
por: Takenaka, Yasuhiro, et al.
Publicado: (2013)

Lysophosphatidylcholine for Efficient Intestinal Lipid Absorption And Lipoprotein Secretion in Caco-2 Cells
por: Nakano, Takanari, et al.
Publicado: (2009)

Activating Effect of Benzbromarone, a Uricosuric Drug, on Peroxisome Proliferator-Activated Receptors
por: Kunishima, Chiyoko, et al.
Publicado: (2007)

Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα
por: Chen, Hai-Xin, et al.
Publicado: (2022)

An Ideal PPAR Response Element Bound to and Activated by PPARα
por: Tzeng, John, et al.
Publicado: (2015)

(+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα–FGF21 Pathway
por: Xi, Yiyuan, et al.
Publicado: (2021)

Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation
por: Bort, Alicia, et al.
Publicado: (2019)

The Role of PPARα Activation in Liver and Muscle
por: Burri, Lena, et al.
Publicado: (2010)

Overexpression of salusin-α upregulates AdipoR2 and activates the PPARα/ApoA5/SREBP-1c pathway to inhibit lipid synthesis in HepG2 cells
por: Zhang, Huan, et al.
Publicado: (2023)

Metabolomics of the interaction between PPAR-α and age in the PPAR-α-null mouse
por: Atherton, Helen J, et al.
Publicado: (2009)

Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
por: Tsukamoto, Tomoko, et al.
Publicado: (2010)

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors
por: Dietz, Michel, et al.
Publicado: (2012)

PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists
por: Silswal, Neerupma, et al.
Publicado: (2012)

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
por: Orozco Morales, M. Lizeth, et al.
Publicado: (2021)

PPARα and Effects of TCE
por: Klaunig, James E., et al.
Publicado: (2007)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production
por: Wang, Chaoqun, et al.
Publicado: (2021)

The 4′-Hydroxyl Group of Resveratrol Is Functionally Important for Direct Activation of PPARα
por: Takizawa, Yoshie, et al.
Publicado: (2015)

Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice
por: Kimura, Takefumi, et al.
Publicado: (2012)

The regulation of catalase activity by PPAR γ is affected by α-synuclein
por: Yakunin, Eugenia, et al.
Publicado: (2014)

The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation
por: Wang, Wenwen, et al.
Publicado: (2018)

PPARα activation protects against cholestatic liver injury
por: Zhao, Qi, et al.
Publicado: (2017)

PPARα activation directly upregulates thrombomodulin in the diabetic retina
por: Shiono, Akira, et al.
Publicado: (2020)

Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice
por: Michalik, Liliane, et al.
Publicado: (2001)

The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders
por: Porcuna, Jesús, et al.
Publicado: (2021)

PPARα- and DEHP-Induced Cancers
por: Ito, Yuki, et al.
Publicado: (2008)

Peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARβ/δ) gene expression profile on ram spermatozoa and their relation to the sperm motility
por: Kadivar, Ali, et al.
Publicado: (2016)

PPARα/γ-Independent Effects of PPARα/γ Ligands on Cysteinyl Leukotriene Production in Mast Cells
por: Yamashita, Masamichi
Publicado: (2008)

PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers
por: Shizu, Ryota, et al.
Publicado: (2023)

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
por: Shizu, Ryota, et al.
Publicado: (2021)

Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models
por: Jain, Mukul R, et al.
Publicado: (2015)

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
por: Syversen, Unni, et al.
Publicado: (2009)

Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition
por: Tian, Siyu, et al.
Publicado: (2021)

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
por: Kroon, Tobias, et al.
Publicado: (2020)

Alleviation of Toxicity Caused by Overactivation of Pparα through Pparα-Inducible miR-181a2
por: Cheng, Yanjie, et al.
Publicado: (2017)

Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ)
por: Takada, Ichiro, et al.
Publicado: (2013)

Effects and mechanisms of PPARα activator fenofibrate on myocardial remodelling in hypertension
por: Li, Chuan-Bao, et al.
Publicado: (2009)

Early microRNA indicators of PPARα pathway activation in the liver
por: Chorley, Brian N., et al.
Publicado: (2020)

Selective activation of PPARα maintains thermogenic capacity of beige adipocytes
por: Egusa, Gentaro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7b64hplack8in0vrli9gadrgue