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Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

The phenotypes of single- (SKO) and double-knockout (DKO) lines of dihydrofolate reductase–thymidylate synthase (DHFR–TS) of bloodstream Trypanosoma brucei were evaluated in vitro and in vivo. Growth of SKO in vitro is identical to wild-type (WT) cells, whereas DKO has an absolute requirement for th...

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Detalles Bibliográficos
Autores principales:	Sienkiewicz, Natasha, Jarosławski, Szymon, Wyllie, Susan, Fairlamb, Alan H
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610392/ https://www.ncbi.nlm.nih.gov/pubmed/18557814 http://dx.doi.org/10.1111/j.1365-2958.2008.06305.x

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