The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals

BACKGROUND: APOBEC3 (A3) proteins deaminate DNA cytosines and block the replication of retroviruses and retrotransposons. Each A3 gene encodes a protein with one or two conserved zinc-coordinating motifs (Z1, Z2 or Z3). The presence of one A3 gene in mice (Z2–Z3) and seven in humans, A3A-H (Z1a, Z2a...

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Detalles Bibliográficos
Autores principales: LaRue, Rebecca S, Jónsson, Stefán R, Silverstein, Kevin AT, Lajoie, Mathieu, Bertrand, Denis, El-Mabrouk, Nadia, Hötzel, Isidro, Andrésdóttir, Valgerdur, Smith, Timothy PL, Harris, Reuben S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612020/
https://www.ncbi.nlm.nih.gov/pubmed/19017397
http://dx.doi.org/10.1186/1471-2199-9-104

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