Cargando…

Accelerated genetic drift on chromosome X during the human dispersal out of Africa

Comparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as the forces of natural selection. We compared the patterns of variation in these parts of the genome using two data sets that we assembled for this study that are both genomic in...

Descripción completa

Detalles Bibliográficos
Autores principales: Keinan, Alon, Mullikin, James C., Patterson, Nick, Reich, David
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612098/
https://www.ncbi.nlm.nih.gov/pubmed/19098910
http://dx.doi.org/10.1038/ng.303
_version_ 1782163119828631552
author Keinan, Alon
Mullikin, James C.
Patterson, Nick
Reich, David
author_facet Keinan, Alon
Mullikin, James C.
Patterson, Nick
Reich, David
author_sort Keinan, Alon
collection PubMed
description Comparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as the forces of natural selection. We compared the patterns of variation in these parts of the genome using two data sets that we assembled for this study that are both genomic in scale. Three independent analyses show that around the time of the dispersal of modern humans out of Africa, chromosome X experienced much more genetic drift than is expected from the pattern on the autosomes. This is not predicted by known episodes of demographic history, and we found no similar patterns associated with the dispersals into East Asia and Europe. We conclude that a gender-biased process that reduced the female effective population size, or an episode of natural selection unusually affecting chromosome X, was associated with the founding of non-African populations.
format Text
id pubmed-2612098
institution National Center for Biotechnology Information
language English
publishDate 2008
record_format MEDLINE/PubMed
spelling pubmed-26120982009-07-01 Accelerated genetic drift on chromosome X during the human dispersal out of Africa Keinan, Alon Mullikin, James C. Patterson, Nick Reich, David Nat Genet Article Comparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as the forces of natural selection. We compared the patterns of variation in these parts of the genome using two data sets that we assembled for this study that are both genomic in scale. Three independent analyses show that around the time of the dispersal of modern humans out of Africa, chromosome X experienced much more genetic drift than is expected from the pattern on the autosomes. This is not predicted by known episodes of demographic history, and we found no similar patterns associated with the dispersals into East Asia and Europe. We conclude that a gender-biased process that reduced the female effective population size, or an episode of natural selection unusually affecting chromosome X, was associated with the founding of non-African populations. 2008-12-21 2009-01 /pmc/articles/PMC2612098/ /pubmed/19098910 http://dx.doi.org/10.1038/ng.303 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Keinan, Alon
Mullikin, James C.
Patterson, Nick
Reich, David
Accelerated genetic drift on chromosome X during the human dispersal out of Africa
title Accelerated genetic drift on chromosome X during the human dispersal out of Africa
title_full Accelerated genetic drift on chromosome X during the human dispersal out of Africa
title_fullStr Accelerated genetic drift on chromosome X during the human dispersal out of Africa
title_full_unstemmed Accelerated genetic drift on chromosome X during the human dispersal out of Africa
title_short Accelerated genetic drift on chromosome X during the human dispersal out of Africa
title_sort accelerated genetic drift on chromosome x during the human dispersal out of africa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612098/
https://www.ncbi.nlm.nih.gov/pubmed/19098910
http://dx.doi.org/10.1038/ng.303
work_keys_str_mv AT keinanalon acceleratedgeneticdriftonchromosomexduringthehumandispersaloutofafrica
AT mullikinjamesc acceleratedgeneticdriftonchromosomexduringthehumandispersaloutofafrica
AT pattersonnick acceleratedgeneticdriftonchromosomexduringthehumandispersaloutofafrica
AT reichdavid acceleratedgeneticdriftonchromosomexduringthehumandispersaloutofafrica