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Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins
DEF-like and GLO-like class B floral homeotic genes encode closely related MADS-domain transcription factors that act as developmental switches involved in specifying the identity of petals and stamens during flower development. Class B gene function requires transcriptional upregulation by an autor...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612583/ https://www.ncbi.nlm.nih.gov/pubmed/19148269 http://dx.doi.org/10.1371/journal.pcbi.1000264 |
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author | Lenser, Thorsten Theißen, Günter Dittrich, Peter |
author_facet | Lenser, Thorsten Theißen, Günter Dittrich, Peter |
author_sort | Lenser, Thorsten |
collection | PubMed |
description | DEF-like and GLO-like class B floral homeotic genes encode closely related MADS-domain transcription factors that act as developmental switches involved in specifying the identity of petals and stamens during flower development. Class B gene function requires transcriptional upregulation by an autoregulatory loop that depends on obligate heterodimerization of DEF-like and GLO-like proteins. Because switch-like behavior of gene expression can be displayed by single genes already, the functional relevance of this complex circuitry has remained enigmatic. On the basis of a stochastic in silico model of class B gene and protein interactions, we suggest that obligate heterodimerization of class B floral homeotic proteins is not simply the result of neutral drift but enhanced the robustness of cell-fate organ identity decisions in the presence of stochastic noise. This finding strongly corroborates the view that the appearance of this regulatory mechanism during angiosperm phylogeny led to a canalization of flower development and evolution. |
format | Text |
id | pubmed-2612583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26125832009-01-16 Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins Lenser, Thorsten Theißen, Günter Dittrich, Peter PLoS Comput Biol Research Article DEF-like and GLO-like class B floral homeotic genes encode closely related MADS-domain transcription factors that act as developmental switches involved in specifying the identity of petals and stamens during flower development. Class B gene function requires transcriptional upregulation by an autoregulatory loop that depends on obligate heterodimerization of DEF-like and GLO-like proteins. Because switch-like behavior of gene expression can be displayed by single genes already, the functional relevance of this complex circuitry has remained enigmatic. On the basis of a stochastic in silico model of class B gene and protein interactions, we suggest that obligate heterodimerization of class B floral homeotic proteins is not simply the result of neutral drift but enhanced the robustness of cell-fate organ identity decisions in the presence of stochastic noise. This finding strongly corroborates the view that the appearance of this regulatory mechanism during angiosperm phylogeny led to a canalization of flower development and evolution. Public Library of Science 2009-01-16 /pmc/articles/PMC2612583/ /pubmed/19148269 http://dx.doi.org/10.1371/journal.pcbi.1000264 Text en Lenser et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lenser, Thorsten Theißen, Günter Dittrich, Peter Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins |
title | Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins |
title_full | Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins |
title_fullStr | Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins |
title_full_unstemmed | Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins |
title_short | Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins |
title_sort | developmental robustness by obligate interaction of class b floral homeotic genes and proteins |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612583/ https://www.ncbi.nlm.nih.gov/pubmed/19148269 http://dx.doi.org/10.1371/journal.pcbi.1000264 |
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