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Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report

BACKGROUND: We report a case of a 53 year old lady recently commenced on etanercept, an anti-TNF (tumour necrosis factor) therapy for rheumatoid arthritis presenting with confusion, pyrexia and an erythematous rash. CASE PRESENTATION: A lumbar puncture was highly suggestive of bacterial meningitis,...

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Detalles Bibliográficos
Autores principales: Booker, Matthew J, Flint, Julia, Saravana, Shanmugam
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612655/
https://www.ncbi.nlm.nih.gov/pubmed/19046446
http://dx.doi.org/10.1186/1757-1626-1-364
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author Booker, Matthew J
Flint, Julia
Saravana, Shanmugam
author_facet Booker, Matthew J
Flint, Julia
Saravana, Shanmugam
author_sort Booker, Matthew J
collection PubMed
description BACKGROUND: We report a case of a 53 year old lady recently commenced on etanercept, an anti-TNF (tumour necrosis factor) therapy for rheumatoid arthritis presenting with confusion, pyrexia and an erythematous rash. CASE PRESENTATION: A lumbar puncture was highly suggestive of bacterial meningitis, but CSF cultures produced no growth, and polymerase chain reactions (PCR) for all previously reported bacterial, fungal and viral causes of meningitis were negative. CONCLUSION: This case report describes aseptic meningitis as a previously unreported complication of etanercept therapy, and serves as a reminder of the rare but potentially life-threatening risk of serious infections in patients taking anti-TNF therapy for a variety of conditions.
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spelling pubmed-26126552008-12-31 Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report Booker, Matthew J Flint, Julia Saravana, Shanmugam Cases J Case Report BACKGROUND: We report a case of a 53 year old lady recently commenced on etanercept, an anti-TNF (tumour necrosis factor) therapy for rheumatoid arthritis presenting with confusion, pyrexia and an erythematous rash. CASE PRESENTATION: A lumbar puncture was highly suggestive of bacterial meningitis, but CSF cultures produced no growth, and polymerase chain reactions (PCR) for all previously reported bacterial, fungal and viral causes of meningitis were negative. CONCLUSION: This case report describes aseptic meningitis as a previously unreported complication of etanercept therapy, and serves as a reminder of the rare but potentially life-threatening risk of serious infections in patients taking anti-TNF therapy for a variety of conditions. BioMed Central 2008-12-01 /pmc/articles/PMC2612655/ /pubmed/19046446 http://dx.doi.org/10.1186/1757-1626-1-364 Text en Copyright © 2008 Booker et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Booker, Matthew J
Flint, Julia
Saravana, Shanmugam
Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
title Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
title_full Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
title_fullStr Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
title_full_unstemmed Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
title_short Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
title_sort aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612655/
https://www.ncbi.nlm.nih.gov/pubmed/19046446
http://dx.doi.org/10.1186/1757-1626-1-364
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