In vivo silencing of alpha-synuclein using naked siRNA

BACKGROUND: Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a r...

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Detalles Bibliográficos
Autores principales: Lewis, Jada, Melrose, Heather, Bumcrot, David, Hope, Andrew, Zehr, Cynthia, Lincoln, Sarah, Braithwaite, Adam, He, Zhen, Ogholikhan, Sina, Hinkle, Kelly, Kent, Caroline, Toudjarska, Ivanka, Charisse, Klaus, Braich, Ravi, Pandey, Rajendra K, Heckman, Michael, Maraganore, Demetrius M, Crook, Julia, Farrer, Matthew J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612658/
https://www.ncbi.nlm.nih.gov/pubmed/18976489
http://dx.doi.org/10.1186/1750-1326-3-19

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