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Chromosomal mosaicism goes global

Intercellular differences of chromosomal content in the same individual are defined as chromosomal mosaicism (alias intercellular or somatic genomic variations or, in a number of publications, mosaic aneuploidy). It has long been suggested that this phenomenon poorly contributes both to intercellula...

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Autores principales: Iourov, Ivan Y, Vorsanova, Svetlana G, Yurov, Yuri B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612668/
https://www.ncbi.nlm.nih.gov/pubmed/19032785
http://dx.doi.org/10.1186/1755-8166-1-26
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author Iourov, Ivan Y
Vorsanova, Svetlana G
Yurov, Yuri B
author_facet Iourov, Ivan Y
Vorsanova, Svetlana G
Yurov, Yuri B
author_sort Iourov, Ivan Y
collection PubMed
description Intercellular differences of chromosomal content in the same individual are defined as chromosomal mosaicism (alias intercellular or somatic genomic variations or, in a number of publications, mosaic aneuploidy). It has long been suggested that this phenomenon poorly contributes both to intercellular (interindividual) diversity and to human disease. However, our views have recently become to change due to a series of communications demonstrated a higher incidence of chromosomal mosaicism in diseased individuals (major psychiatric disorders and autoimmune diseases) as well as depicted chromosomal mosaicism contribution to genetic diversity, the central nervous system development, and aging. The later has been produced by significant achievements in the field of molecular cytogenetics. Recently, Molecular Cytogenetics has published an article by Maj Hulten and colleagues that has provided evidences for chromosomal mosaicism to underlie formation of germline aneuploidy in human female gametes using trisomy 21 (Down syndrome) as a model. Since meiotic aneuploidy is suggested to be the leading genetic cause of human prenatal mortality and postnatal morbidity, these data together with previous findings define chromosomal mosaicism not as a casual finding during cytogenetic analyses but as a more significant biological phenomenon than previously recognized. Finally, the significance of chromosomal mosaicism can be drawn from the fact, that this phenomenon is involved in genetic diversity, normal and abnormal prenatal development, human diseases, aging, and meiotic aneuploidy, the intrinsic cause of which remains, as yet, unknown.
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spelling pubmed-26126682008-12-31 Chromosomal mosaicism goes global Iourov, Ivan Y Vorsanova, Svetlana G Yurov, Yuri B Mol Cytogenet Editorial Intercellular differences of chromosomal content in the same individual are defined as chromosomal mosaicism (alias intercellular or somatic genomic variations or, in a number of publications, mosaic aneuploidy). It has long been suggested that this phenomenon poorly contributes both to intercellular (interindividual) diversity and to human disease. However, our views have recently become to change due to a series of communications demonstrated a higher incidence of chromosomal mosaicism in diseased individuals (major psychiatric disorders and autoimmune diseases) as well as depicted chromosomal mosaicism contribution to genetic diversity, the central nervous system development, and aging. The later has been produced by significant achievements in the field of molecular cytogenetics. Recently, Molecular Cytogenetics has published an article by Maj Hulten and colleagues that has provided evidences for chromosomal mosaicism to underlie formation of germline aneuploidy in human female gametes using trisomy 21 (Down syndrome) as a model. Since meiotic aneuploidy is suggested to be the leading genetic cause of human prenatal mortality and postnatal morbidity, these data together with previous findings define chromosomal mosaicism not as a casual finding during cytogenetic analyses but as a more significant biological phenomenon than previously recognized. Finally, the significance of chromosomal mosaicism can be drawn from the fact, that this phenomenon is involved in genetic diversity, normal and abnormal prenatal development, human diseases, aging, and meiotic aneuploidy, the intrinsic cause of which remains, as yet, unknown. BioMed Central 2008-11-25 /pmc/articles/PMC2612668/ /pubmed/19032785 http://dx.doi.org/10.1186/1755-8166-1-26 Text en Copyright © 2008 Iourov et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Iourov, Ivan Y
Vorsanova, Svetlana G
Yurov, Yuri B
Chromosomal mosaicism goes global
title Chromosomal mosaicism goes global
title_full Chromosomal mosaicism goes global
title_fullStr Chromosomal mosaicism goes global
title_full_unstemmed Chromosomal mosaicism goes global
title_short Chromosomal mosaicism goes global
title_sort chromosomal mosaicism goes global
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612668/
https://www.ncbi.nlm.nih.gov/pubmed/19032785
http://dx.doi.org/10.1186/1755-8166-1-26
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