Mutations on the Switch III region and the alpha3 helix of Galpha(16 )differentially affect receptor coupling and regulation of downstream effectors

BACKGROUND: Gα(16 )can activate phospholipase Cβ (PLCβ) directly like Gα(q). It also couples to tetratricopeptide repeat 1 (TPR1) which is linked to Ras activation. It is unknown whether PLCβ and TPR1 interact with the same regions on Gα(16). Previous studies on Gα(q )have defined two minimal cluste...

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Detalles Bibliográficos
Autores principales: Yu, May YM, Ho, Maurice KC, Liu, Andrew MF, Wong, Yung H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613389/
https://www.ncbi.nlm.nih.gov/pubmed/19025606
http://dx.doi.org/10.1186/1750-2187-3-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613389/
https://www.ncbi.nlm.nih.gov/pubmed/19025606
http://dx.doi.org/10.1186/1750-2187-3-17

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