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Mutations on the Switch III region and the alpha3 helix of Galpha(16 )differentially affect receptor coupling and regulation of downstream effectors
BACKGROUND: Gα(16 )can activate phospholipase Cβ (PLCβ) directly like Gα(q). It also couples to tetratricopeptide repeat 1 (TPR1) which is linked to Ras activation. It is unknown whether PLCβ and TPR1 interact with the same regions on Gα(16). Previous studies on Gα(q )have defined two minimal cluste...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613389/ https://www.ncbi.nlm.nih.gov/pubmed/19025606 http://dx.doi.org/10.1186/1750-2187-3-17 |