Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27(Kip1 )or p21(Cip1)

BACKGROUND: The antihyperglycemic drug metformin may have beneficial effects on the prevention and treatment of cancer. Metformin is known to activate AMP-activated protein kinase (AMPK). It has also been shown to inhibit cyclin D1 expression and proliferation of some cultured cancer cells. However,...

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Detalles Bibliográficos
Autores principales: Zhuang, Yongxian, Miskimins, W Keith
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613390/
https://www.ncbi.nlm.nih.gov/pubmed/19046439
http://dx.doi.org/10.1186/1750-2187-3-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613390/
https://www.ncbi.nlm.nih.gov/pubmed/19046439
http://dx.doi.org/10.1186/1750-2187-3-18

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