Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report

BACKGROUND: Transfusion related acute lung injury (TRALI) is a potentially fatal Acute Lung Injury following transfusion of blood components. Hypotheses implicate donor-derived anti-human leukocyte antigen or granulocyte antibodies reacting with recipients' leukocytes, releasing inflammatory me...

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Autores principales: Bawany, Fauzia Ahmad, Sharif, Hasanat
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613407/
https://www.ncbi.nlm.nih.gov/pubmed/19055759
http://dx.doi.org/10.1186/1757-1626-1-372
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author Bawany, Fauzia Ahmad
Sharif, Hasanat
author_facet Bawany, Fauzia Ahmad
Sharif, Hasanat
author_sort Bawany, Fauzia Ahmad
collection PubMed
description BACKGROUND: Transfusion related acute lung injury (TRALI) is a potentially fatal Acute Lung Injury following transfusion of blood components. Hypotheses implicate donor-derived anti-human leukocyte antigen or granulocyte antibodies reacting with recipients' leukocytes, releasing inflammatory mediators. Lack of agreement on underlying cellular and molecular mechanisms renders improving transfusion safety difficult and expensive. CASE PRESENTATION: Literature search has not revealed any case of TRALI from Pakistan. We report the case of fatal TRALI in a 68 year old male who received blood products after coronary artery by-pass surgery. CONCLUSION: This article aims to create awareness about this complication and suggests that post transfusion cardiopulmonary instability should alert to the possibility of TRALI.
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spelling pubmed-26134072009-01-03 Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report Bawany, Fauzia Ahmad Sharif, Hasanat Cases J Case Report BACKGROUND: Transfusion related acute lung injury (TRALI) is a potentially fatal Acute Lung Injury following transfusion of blood components. Hypotheses implicate donor-derived anti-human leukocyte antigen or granulocyte antibodies reacting with recipients' leukocytes, releasing inflammatory mediators. Lack of agreement on underlying cellular and molecular mechanisms renders improving transfusion safety difficult and expensive. CASE PRESENTATION: Literature search has not revealed any case of TRALI from Pakistan. We report the case of fatal TRALI in a 68 year old male who received blood products after coronary artery by-pass surgery. CONCLUSION: This article aims to create awareness about this complication and suggests that post transfusion cardiopulmonary instability should alert to the possibility of TRALI. BioMed Central 2008-12-03 /pmc/articles/PMC2613407/ /pubmed/19055759 http://dx.doi.org/10.1186/1757-1626-1-372 Text en Copyright © 2008 Bawany and Sharif; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bawany, Fauzia Ahmad
Sharif, Hasanat
Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
title Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
title_full Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
title_fullStr Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
title_full_unstemmed Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
title_short Fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
title_sort fatal transfusion related acute lung injury following coronary artery by-pass surgery: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613407/
https://www.ncbi.nlm.nih.gov/pubmed/19055759
http://dx.doi.org/10.1186/1757-1626-1-372
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AT sharifhasanat fataltransfusionrelatedacutelunginjuryfollowingcoronaryarterybypasssurgeryacasereport

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