Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever

Background to the debate: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagn...

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Autores principales: D'Acremont, Valérie, Lengeler, Christian, Mshinda, Hassan, Mtasiwa, Deo, Tanner, Marcel, Genton, Blaise
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
The PLoS Medicine Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613421/
https://www.ncbi.nlm.nih.gov/pubmed/19127974
http://dx.doi.org/10.1371/journal.pmed.0050252
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author D'Acremont, Valérie
Lengeler, Christian
Mshinda, Hassan
Mtasiwa, Deo
Tanner, Marcel
Genton, Blaise
author_facet D'Acremont, Valérie
Lengeler, Christian
Mshinda, Hassan
Mtasiwa, Deo
Tanner, Marcel
Genton, Blaise
author_sort D'Acremont, Valérie
collection PubMed
description Background to the debate: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagnostic tests mean it may be time for this policy to change. This debate examines whether enough evidence exists to support abandoning presumptive treatment and whether African health systems have the capacity to support a shift toward laboratory-confirmed rather than presumptive diagnosis and treatment of malaria in children under five.
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spelling pubmed-26134212009-01-06 Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever D'Acremont, Valérie Lengeler, Christian Mshinda, Hassan Mtasiwa, Deo Tanner, Marcel Genton, Blaise PLoS Med The PLoS Medicine Debate Background to the debate: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagnostic tests mean it may be time for this policy to change. This debate examines whether enough evidence exists to support abandoning presumptive treatment and whether African health systems have the capacity to support a shift toward laboratory-confirmed rather than presumptive diagnosis and treatment of malaria in children under five. Public Library of Science 2009-01 2009-01-06 /pmc/articles/PMC2613421/ /pubmed/19127974 http://dx.doi.org/10.1371/journal.pmed.0050252 Text en © 2009 D'Acremont et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle The PLoS Medicine Debate
D'Acremont, Valérie
Lengeler, Christian
Mshinda, Hassan
Mtasiwa, Deo
Tanner, Marcel
Genton, Blaise
Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
title Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
title_full Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
title_fullStr Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
title_full_unstemmed Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
title_short Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
title_sort time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in african children with fever
topic The PLoS Medicine Debate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613421/
https://www.ncbi.nlm.nih.gov/pubmed/19127974
http://dx.doi.org/10.1371/journal.pmed.0050252
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