Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility

Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. However, prior to lineage commitment, genes are primed at low expression levels. Understanding the underlying molecular circuitry in terms of how it governs both a primed state and...

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Detalles Bibliográficos
Autores principales: Chickarmane, Vijay, Enver, Tariq, Peterson, Carsten
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613533/
https://www.ncbi.nlm.nih.gov/pubmed/19165316
http://dx.doi.org/10.1371/journal.pcbi.1000268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613533/
https://www.ncbi.nlm.nih.gov/pubmed/19165316
http://dx.doi.org/10.1371/journal.pcbi.1000268

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