Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors

Tumor sections from nonneoplastic (n = 15), benign (n = 28), and malignant ovarian tumors (n = 20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneopla...

Descripción completa

Detalles Bibliográficos
Autores principales: Nomelini, Rosekeila Simões, Ribeiro, Lívia Carolina de Abreu, Tavares-Murta, Beatriz Martins, Adad, Sheila Jorge, Murta, Eddie Fernando Candido
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613969/
https://www.ncbi.nlm.nih.gov/pubmed/19132106
http://dx.doi.org/10.1155/2008/186584
_version_ 1782163216567107584
author Nomelini, Rosekeila Simões
Ribeiro, Lívia Carolina de Abreu
Tavares-Murta, Beatriz Martins
Adad, Sheila Jorge
Murta, Eddie Fernando Candido
author_facet Nomelini, Rosekeila Simões
Ribeiro, Lívia Carolina de Abreu
Tavares-Murta, Beatriz Martins
Adad, Sheila Jorge
Murta, Eddie Fernando Candido
author_sort Nomelini, Rosekeila Simões
collection PubMed
description Tumor sections from nonneoplastic (n = 15), benign (n = 28), and malignant ovarian tumors (n = 20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P < .05). For stage I ovarian cancer, intracystic NO levels >80 μM were more frequent than NO levels <80 μM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P < .05). These data suggest an important role for NO in ovarian carcinogenesis.
format Text
id pubmed-2613969
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-26139692009-01-08 Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors Nomelini, Rosekeila Simões Ribeiro, Lívia Carolina de Abreu Tavares-Murta, Beatriz Martins Adad, Sheila Jorge Murta, Eddie Fernando Candido Mediators Inflamm Clinical Study Tumor sections from nonneoplastic (n = 15), benign (n = 28), and malignant ovarian tumors (n = 20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P < .05). For stage I ovarian cancer, intracystic NO levels >80 μM were more frequent than NO levels <80 μM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P < .05). These data suggest an important role for NO in ovarian carcinogenesis. Hindawi Publishing Corporation 2008 2009-01-05 /pmc/articles/PMC2613969/ /pubmed/19132106 http://dx.doi.org/10.1155/2008/186584 Text en Copyright © 2008 Rosekeila Simões Nomelini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Nomelini, Rosekeila Simões
Ribeiro, Lívia Carolina de Abreu
Tavares-Murta, Beatriz Martins
Adad, Sheila Jorge
Murta, Eddie Fernando Candido
Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
title Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
title_full Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
title_fullStr Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
title_full_unstemmed Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
title_short Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
title_sort production of nitric oxide and expression of inducible nitric oxide synthase in ovarian cystic tumors
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613969/
https://www.ncbi.nlm.nih.gov/pubmed/19132106
http://dx.doi.org/10.1155/2008/186584
work_keys_str_mv AT nomelinirosekeilasimoes productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors
AT ribeiroliviacarolinadeabreu productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors
AT tavaresmurtabeatrizmartins productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors
AT adadsheilajorge productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors
AT murtaeddiefernandocandido productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors

Ejemplares similares