Cargando…

An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms

Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. Analyses of disease-causing mutations in familial nephrotic syndromes and tar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hirose, Tomonori, Satoh, Daisuke, Kurihara, Hidetake, Kusaka, Chiho, Hirose, Hiroko, Akimoto, Kazunori, Matsusaka, Taiji, Ichikawa, Iekuni, Noda, Tetsuo, Ohno, Shigeo
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614475/ https://www.ncbi.nlm.nih.gov/pubmed/19142224 http://dx.doi.org/10.1371/journal.pone.0004194

Ejemplares similares

aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface
por: Satoh, Daisuke, et al.
Publicado: (2014)

Loss of aPKCλ in Differentiated Neurons Disrupts the Polarity Complex but Does Not Induce Obvious Neuronal Loss or Disorientation in Mouse Brains
por: Yamanaka, Tomoyuki, et al.
Publicado: (2013)

A cell polarity protein aPKCλ is required for eye lens formation and growth
por: Sugiyama, Yuki, et al.
Publicado: (2009)

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis
por: Vorhagen, Susanne, et al.
Publicado: (2018)

Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
por: Swiatecka-Urban, Agnieszka
Publicado: (2017)

Hypoxia decreases podocyte expression of slit diaphragm proteins
por: Lu, Hong, et al.
Publicado: (2012)

Lack of an association between the aPKCλ/ι expression in prostate cancer and the patient outcomes
por: Yokomizo, Yumiko, et al.
Publicado: (2017)

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes
por: Tanigawa, Shunsuke, et al.
Publicado: (2018)

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation
por: Niessen, Michaela T., et al.
Publicado: (2013)

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach
por: Yu, Samuel Mon-Wei, et al.
Publicado: (2018)

New insight into podocyte slit diaphragm, a therapeutic target of proteinuria
por: Kawachi, Hiroshi, et al.
Publicado: (2020)

Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm
por: van de Leemput, Joyce, et al.
Publicado: (2022)

Inactivation of aPKCλ Reveals a Context Dependent Allocation of Cell Lineages in Preimplantation Mouse Embryos
por: Dard, Nicolas, et al.
Publicado: (2009)

The Structural and Functional Organization of the Podocyte Filtration Slits Is Regulated by Tjp1/ZO-1
por: Itoh, Masahiko, et al.
Publicado: (2014)

IQGAP1 Interacts with Components of the Slit Diaphragm Complex in Podocytes and Is Involved in Podocyte Migration and Permeability In Vitro
por: Rigothier, Claire, et al.
Publicado: (2012)

CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney
por: Nyström, Jenny, et al.
Publicado: (2009)

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
por: Weavers, Helen, et al.
Publicado: (2008)

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond
por: Martin, Claire E., et al.
Publicado: (2018)

aPKC: the Kinase that Phosphorylates Cell Polarity
por: Hong, Yang
Publicado: (2018)

aPKC in neuronal differentiation, maturation and function
por: Hapak, Sophie M., et al.
Publicado: (2019)

WWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin
por: Lin, Ting, et al.
Publicado: (2017)

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
por: Riddell, Meghan, et al.
Publicado: (2018)

The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity
por: Yoshihama, Yohei, et al.
Publicado: (2012)

Altered Expression of Par3, aPKC-λ, and Lgl1 in Hippocampus in Kainic Acid-Induced Status Epilepticus Rat Model
por: Zhang, Chen, et al.
Publicado: (2021)

mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes
por: Spitz, Dominik, et al.
Publicado: (2022)

Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair
por: Solanki, Ashish K., et al.
Publicado: (2021)

MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes
por: Ni, Jie, et al.
Publicado: (2016)

Nup358 interacts with Dishevelled and aPKC to regulate neuronal polarity
por: Vyas, Pankhuri, et al.
Publicado: (2013)

aPKC Phosphorylation of HDAC6 Results in Increased Deacetylation Activity
por: Du, Yifeng, et al.
Publicado: (2015)

Regulation of aPKC activity by Nup358 dependent SUMO modification
por: Yadav, Santosh Kumar, et al.
Publicado: (2016)

Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm
por: Wakamatsu, Ayako, et al.
Publicado: (2016)

Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
por: Rolls, Melissa M., et al.
Publicado: (2003)

Sodium hydrogen sulfide (NaHS) ameliorates alterations caused by cisplatin in filtration slit diaphragm and podocyte cytoskeletal in rat kidney
por: Karimi, Asiyeh, et al.
Publicado: (2017)

Numb controls E-cadherin endocytosis through p120 catenin with aPKC
por: Sato, Kazuhide, et al.
Publicado: (2011)

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
por: Leong, Gregory R, et al.
Publicado: (2009)

Complex Interactions between GSK3 and aPKC in Drosophila Embryonic Epithelial Morphogenesis
por: Kaplan, Nicole A., et al.
Publicado: (2011)

aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells
por: Morais-de-Sá, Eurico, et al.
Publicado: (2010)

Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation
por: Röper, Katja
Publicado: (2012)

Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity
por: Morais-de-Sá, Eurico, et al.
Publicado: (2014)

Gli activation by aPKC iota/lambda regulates basal cell carcinoma growth
por: Atwood, Scott X., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4geadmegjirb7hf9g0s50e56qh