Cargando…

The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast

Nuclear pore complexes (NPCs) mediate all nucleocytoplasmic traffic and provide docking sites for the spindle assembly checkpoint (SAC) protein Mad1p. Upon SAC activation, Mad1p is recruited onto kinetochores and rapidly cycles between NPCs and kinetochores. We examined the mechanism of Mad1p moveme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scott, Robert J., Cairo, Lucas V., Van de Vosse, David W., Wozniak, Richard W.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615093/ https://www.ncbi.nlm.nih.gov/pubmed/19139260 http://dx.doi.org/10.1083/jcb.200804098

Ejemplares similares

XPO1-dependent nuclear export as a target for cancer therapy
por: Azizian, Nancy G., et al.
Publicado: (2020)

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
por: Sexton, Rachel, et al.
Publicado: (2019)

Nuclear Export in Non-Hodgkin Lymphoma and Implications for Targeted XPO1 Inhibitors
por: Trkulja, Kyla L., et al.
Publicado: (2023)

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition
por: Azmi, Asfar S., et al.
Publicado: (2015)

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB
por: Galinski, Basia, et al.
Publicado: (2021)

Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
por: Gargantilla, Marta, et al.
Publicado: (2021)

A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds
por: Crochiere, Marsha L., et al.
Publicado: (2015)

Heterozygous mutation of cysteine(528) in XPO1 is sufficient for resistance to selective inhibitors of nuclear export
por: Neggers, Jasper Edgar, et al.
Publicado: (2016)

Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
por: Zhou, Haining, et al.
Publicado: (2016)

Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1
por: Fischer, Elyse S, et al.
Publicado: (2021)

A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint
por: Moyle, Mark W., et al.
Publicado: (2014)

BUB-1 makes kinetochores MAD
por: Short, Ben
Publicado: (2014)

Proteomics identify nuclear export as a targetable pathway in neuroblastoma: Comment on “XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IκB”
por: Shah, Nilay
Publicado: (2021)

The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila
por: Büssing, Ingo, et al.
Publicado: (2010)

Reversible disruption of XPO1-mediated nuclear export inhibits respiratory syncytial virus (RSV) replication
por: Mathew, Cynthia, et al.
Publicado: (2021)

MAD1: Kinetochore Receptors and Catalytic Mechanisms
por: Luo, Yibo, et al.
Publicado: (2018)

Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection
por: Zhang, Mingzhen, et al.
Publicado: (2022)

Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis
por: Barnhart, Erin L., et al.
Publicado: (2011)

Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185
por: Tabe, Yoko, et al.
Publicado: (2015)

Novel use for selective inhibitors of nuclear export in β-thalassemia: block of HSP70 export from the nucleus via exportin Xpo1 improves ineffective erythropoiesis
por: Modepalli, Susree, et al.
Publicado: (2020)

Rashomon at the kinetochore: Function(s) of the Mad1–cyclin B1 complex
por: Houston, Jack, et al.
Publicado: (2020)

Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin
por: De Cesare, Michelandrea, et al.
Publicado: (2015)

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
por: Maldonado, Maria, et al.
Publicado: (2011)

Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase
por: Kuijt, Timo E. F., et al.
Publicado: (2014)

Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export
por: Grosshans, Helge, et al.
Publicado: (2001)

Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores
por: Heinrich, Stephanie, et al.
Publicado: (2014)

XPO1, therapeutic … and prognostic target in sarcomas
por: Bertucci, François, et al.
Publicado: (2016)

Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint
por: Ballister, Edward R., et al.
Publicado: (2014)

Inheritance of yeast nuclear pore complexes requires the Nsp1p subcomplex
por: Makio, Tadashi, et al.
Publicado: (2013)

Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension
por: Waters, Jennifer C., et al.
Publicado: (1998)

XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)
por: Gravina, Giovanni Luca, et al.
Publicado: (2014)

PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores
por: Montembault, Emilie, et al.
Publicado: (2007)

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint
por: Allan, Lindsey A, et al.
Publicado: (2020)

Control of the spindle checkpoint by lateral kinetochore attachment and limited Mad1 recruitment
por: Krefman, Nathaniel I., et al.
Publicado: (2015)

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores
por: Tighe, Anthony, et al.
Publicado: (2008)

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells
por: Etchin, J, et al.
Publicado: (2017)

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
Publicado: (1995)

Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5
por: Li, Chun, et al.
Publicado: (2023)

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint
por: London, Nitobe, et al.
Publicado: (2014)

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling
por: Alfonso-Pérez, Tatiana, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_sto8kqrdtg5aulci328ttursj9