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USP7 counteracts SCF(βTrCP)- but not APC(Cdh1)-mediated proteolysis of Claspin

Claspin is an adaptor protein that facilitates the ataxia telangiectasia and Rad3-related (ATR)-mediated phosphorylation and activation of Chk1, a key effector kinase in the DNA damage response. Efficient termination of Chk1 signaling in mitosis and during checkpoint recovery requires SCF(βTrCP)-dep...

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Detalles Bibliográficos
Autores principales:	Faustrup, Helene, Bekker-Jensen, Simon, Bartek, Jiri, Lukas, Jiri, Mailand, Niels
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615094/ https://www.ncbi.nlm.nih.gov/pubmed/19124652 http://dx.doi.org/10.1083/jcb.200807137

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