The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway

PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms associated with this pathway have not been elucidated. The Akt-mTOR-P70S...

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Detalles Bibliográficos
Autores principales: Park, Sungha, Lim, Soyeon, Chang, Woochul, Song, Heesang, Lee, Sunju, Song, Byeong-Wook, Kim, Hye-Jung, Cha, Min-Ji, Choi, Eunju, Jang, Yangsoo, Chung, Namsik, Cho, Seung Yun, Hwang, Ki-Chul
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615285/
https://www.ncbi.nlm.nih.gov/pubmed/18729301
http://dx.doi.org/10.3349/ymj.2008.49.4.592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615285/
https://www.ncbi.nlm.nih.gov/pubmed/18729301
http://dx.doi.org/10.3349/ymj.2008.49.4.592

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