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Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium

PURPOSE: The incidence of pain induced withdrawal movement following intravenous injection of rocuronium is high. This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of ro...

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Autores principales: Choi, Byung In, Choi, Seung Ho, Shin, Yang-Sik, Lee, Sung Jin, Yoon, Kyung Bong, Shin, Seo Kyung, Lee, Ki-Young
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615319/
https://www.ncbi.nlm.nih.gov/pubmed/18452256
http://dx.doi.org/10.3349/ymj.2008.49.2.211
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author Choi, Byung In
Choi, Seung Ho
Shin, Yang-Sik
Lee, Sung Jin
Yoon, Kyung Bong
Shin, Seo Kyung
Lee, Ki-Young
author_facet Choi, Byung In
Choi, Seung Ho
Shin, Yang-Sik
Lee, Sung Jin
Yoon, Kyung Bong
Shin, Seo Kyung
Lee, Ki-Young
author_sort Choi, Byung In
collection PubMed
description PURPOSE: The incidence of pain induced withdrawal movement following intravenous injection of rocuronium is high. This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of rocuronium during anesthetic induction. MATERIALS AND METHODS: Ninety adult female patients undergoing thyroidectomy were randomly allocated to three groups. Each patient intravenously received one of three solutions of equal volume (4 mL): normal saline (Group I, n = 30), 0.5 µg/kg remifentanil (Group II, n = 30) or 1 µg/kg remifentanil (Group III, n = 30). Thirty seconds after remifentanil administration, anesthesia was induced with 5 mg/kg IV thiopental. Twenty seconds after thiopental injection, 0.6 mg/kg IV rocuronium was administered (injection rate of 0.5 mL/sec) and patients' withdrawal movements were assessed. Mean arterial pressure (MAP) and heart rate were assessed on arrival in the operation room, before the tracheal intubation and immediately, 1 and 2 min after the tracheal intubation. RESULTS: The incidence of withdrawal movements was significantly lower in both of the remifentanil groups (3 and 0% in Group II and III, respectively) than in the saline group (70%). Remifentanil attenuated the increase of heart rate and MAP immediately and 1 min after the tracheal intubation. CONCLUSION: The pretreatment with 0.5 and 1.0 µg/kg remifentanil of bolus doses prevented the withdrawal movements caused by rocuronium injection, and effectively blunted cardiovascular activation following tracheal intubation.
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spelling pubmed-26153192009-02-02 Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium Choi, Byung In Choi, Seung Ho Shin, Yang-Sik Lee, Sung Jin Yoon, Kyung Bong Shin, Seo Kyung Lee, Ki-Young Yonsei Med J Original Article PURPOSE: The incidence of pain induced withdrawal movement following intravenous injection of rocuronium is high. This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of rocuronium during anesthetic induction. MATERIALS AND METHODS: Ninety adult female patients undergoing thyroidectomy were randomly allocated to three groups. Each patient intravenously received one of three solutions of equal volume (4 mL): normal saline (Group I, n = 30), 0.5 µg/kg remifentanil (Group II, n = 30) or 1 µg/kg remifentanil (Group III, n = 30). Thirty seconds after remifentanil administration, anesthesia was induced with 5 mg/kg IV thiopental. Twenty seconds after thiopental injection, 0.6 mg/kg IV rocuronium was administered (injection rate of 0.5 mL/sec) and patients' withdrawal movements were assessed. Mean arterial pressure (MAP) and heart rate were assessed on arrival in the operation room, before the tracheal intubation and immediately, 1 and 2 min after the tracheal intubation. RESULTS: The incidence of withdrawal movements was significantly lower in both of the remifentanil groups (3 and 0% in Group II and III, respectively) than in the saline group (70%). Remifentanil attenuated the increase of heart rate and MAP immediately and 1 min after the tracheal intubation. CONCLUSION: The pretreatment with 0.5 and 1.0 µg/kg remifentanil of bolus doses prevented the withdrawal movements caused by rocuronium injection, and effectively blunted cardiovascular activation following tracheal intubation. Yonsei University College of Medicine 2008-04-30 2008-04-20 /pmc/articles/PMC2615319/ /pubmed/18452256 http://dx.doi.org/10.3349/ymj.2008.49.2.211 Text en Copyright © 2008 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Byung In
Choi, Seung Ho
Shin, Yang-Sik
Lee, Sung Jin
Yoon, Kyung Bong
Shin, Seo Kyung
Lee, Ki-Young
Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
title Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
title_full Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
title_fullStr Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
title_full_unstemmed Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
title_short Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
title_sort remifentanil prevents withdrawal movements caused by intravenous injection of rocuronium
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615319/
https://www.ncbi.nlm.nih.gov/pubmed/18452256
http://dx.doi.org/10.3349/ymj.2008.49.2.211
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