Cargando…
Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium
PURPOSE: The incidence of pain induced withdrawal movement following intravenous injection of rocuronium is high. This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of ro...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615319/ https://www.ncbi.nlm.nih.gov/pubmed/18452256 http://dx.doi.org/10.3349/ymj.2008.49.2.211 |
_version_ | 1782163313015128064 |
---|---|
author | Choi, Byung In Choi, Seung Ho Shin, Yang-Sik Lee, Sung Jin Yoon, Kyung Bong Shin, Seo Kyung Lee, Ki-Young |
author_facet | Choi, Byung In Choi, Seung Ho Shin, Yang-Sik Lee, Sung Jin Yoon, Kyung Bong Shin, Seo Kyung Lee, Ki-Young |
author_sort | Choi, Byung In |
collection | PubMed |
description | PURPOSE: The incidence of pain induced withdrawal movement following intravenous injection of rocuronium is high. This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of rocuronium during anesthetic induction. MATERIALS AND METHODS: Ninety adult female patients undergoing thyroidectomy were randomly allocated to three groups. Each patient intravenously received one of three solutions of equal volume (4 mL): normal saline (Group I, n = 30), 0.5 µg/kg remifentanil (Group II, n = 30) or 1 µg/kg remifentanil (Group III, n = 30). Thirty seconds after remifentanil administration, anesthesia was induced with 5 mg/kg IV thiopental. Twenty seconds after thiopental injection, 0.6 mg/kg IV rocuronium was administered (injection rate of 0.5 mL/sec) and patients' withdrawal movements were assessed. Mean arterial pressure (MAP) and heart rate were assessed on arrival in the operation room, before the tracheal intubation and immediately, 1 and 2 min after the tracheal intubation. RESULTS: The incidence of withdrawal movements was significantly lower in both of the remifentanil groups (3 and 0% in Group II and III, respectively) than in the saline group (70%). Remifentanil attenuated the increase of heart rate and MAP immediately and 1 min after the tracheal intubation. CONCLUSION: The pretreatment with 0.5 and 1.0 µg/kg remifentanil of bolus doses prevented the withdrawal movements caused by rocuronium injection, and effectively blunted cardiovascular activation following tracheal intubation. |
format | Text |
id | pubmed-2615319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-26153192009-02-02 Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium Choi, Byung In Choi, Seung Ho Shin, Yang-Sik Lee, Sung Jin Yoon, Kyung Bong Shin, Seo Kyung Lee, Ki-Young Yonsei Med J Original Article PURPOSE: The incidence of pain induced withdrawal movement following intravenous injection of rocuronium is high. This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of rocuronium during anesthetic induction. MATERIALS AND METHODS: Ninety adult female patients undergoing thyroidectomy were randomly allocated to three groups. Each patient intravenously received one of three solutions of equal volume (4 mL): normal saline (Group I, n = 30), 0.5 µg/kg remifentanil (Group II, n = 30) or 1 µg/kg remifentanil (Group III, n = 30). Thirty seconds after remifentanil administration, anesthesia was induced with 5 mg/kg IV thiopental. Twenty seconds after thiopental injection, 0.6 mg/kg IV rocuronium was administered (injection rate of 0.5 mL/sec) and patients' withdrawal movements were assessed. Mean arterial pressure (MAP) and heart rate were assessed on arrival in the operation room, before the tracheal intubation and immediately, 1 and 2 min after the tracheal intubation. RESULTS: The incidence of withdrawal movements was significantly lower in both of the remifentanil groups (3 and 0% in Group II and III, respectively) than in the saline group (70%). Remifentanil attenuated the increase of heart rate and MAP immediately and 1 min after the tracheal intubation. CONCLUSION: The pretreatment with 0.5 and 1.0 µg/kg remifentanil of bolus doses prevented the withdrawal movements caused by rocuronium injection, and effectively blunted cardiovascular activation following tracheal intubation. Yonsei University College of Medicine 2008-04-30 2008-04-20 /pmc/articles/PMC2615319/ /pubmed/18452256 http://dx.doi.org/10.3349/ymj.2008.49.2.211 Text en Copyright © 2008 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Byung In Choi, Seung Ho Shin, Yang-Sik Lee, Sung Jin Yoon, Kyung Bong Shin, Seo Kyung Lee, Ki-Young Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium |
title | Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium |
title_full | Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium |
title_fullStr | Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium |
title_full_unstemmed | Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium |
title_short | Remifentanil Prevents Withdrawal Movements Caused by Intravenous Injection of Rocuronium |
title_sort | remifentanil prevents withdrawal movements caused by intravenous injection of rocuronium |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615319/ https://www.ncbi.nlm.nih.gov/pubmed/18452256 http://dx.doi.org/10.3349/ymj.2008.49.2.211 |
work_keys_str_mv | AT choibyungin remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium AT choiseungho remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium AT shinyangsik remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium AT leesungjin remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium AT yoonkyungbong remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium AT shinseokyung remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium AT leekiyoung remifentanilpreventswithdrawalmovementscausedbyintravenousinjectionofrocuronium |