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A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma
PURPOSE: To develop a reliable prognostic model for patients with metastatic renal cell carcinoma (RCC) based on features readily available in common clinical settings. PATIENTS AND METHODS: A total of 197 patients with RCC who underwent nephrectomy and immunotherapy from 1995 to 2004 were retrospec...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Yonsei University College of Medicine
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615339/ https://www.ncbi.nlm.nih.gov/pubmed/18581596 http://dx.doi.org/10.3349/ymj.2008.49.3.451 |
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author | Cho, Kang Su Choi, Young Deuk Kim, Se Joong Kim, Chun Il Chung, Byung Ha Seong, Do Hwan Lee, Dong Hyeon Cho, Jin Seon Cho, In Rae Hong, Sung Joon |
author_facet | Cho, Kang Su Choi, Young Deuk Kim, Se Joong Kim, Chun Il Chung, Byung Ha Seong, Do Hwan Lee, Dong Hyeon Cho, Jin Seon Cho, In Rae Hong, Sung Joon |
author_sort | Cho, Kang Su |
collection | PubMed |
description | PURPOSE: To develop a reliable prognostic model for patients with metastatic renal cell carcinoma (RCC) based on features readily available in common clinical settings. PATIENTS AND METHODS: A total of 197 patients with RCC who underwent nephrectomy and immunotherapy from 1995 to 2004 were retrospectively reviewed. Their mean age was 55.1 ± 11.8 yrs (24 - 83 yrs) and mean survival time from metastasis was 22.6 ± 20.2 mos (3 - 120 mos). The impact of 24 clinicopathological features on disease specific survival was investigated. RESULTS: On univariate analysis, constitutional symptoms, sarcomatoid differentiation, tumor necrosis, multiple primary lesions, liver metastasis, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), thrombocytosis, alkaline phosphatase, hematocrit, T stage, N stage, and nuclear grade had significant influence on survival (p < 0.05). Multivariate analysis revealed the following features associated with survival: sarcomatoid differentiation [hazard ratio (HR) = 2.99, p < 0.001], liver metastasis (HR = 2.09, p = 0.002), ECOG-PS (HR = 1.95, p = 0.005), N stage (HR = 1.94, p = 0.002), and number of metastatic sites (HR = 1.76, p = 0.003). An individual prognostic score was defined as the sum of the weight of these features. According to prognostic scores, patients could be subdivided into 3 groups: low risk (score 0), intermediate risk (score 1 or 2), and high risk (score ≥ 3). CONCLUSION: A comprehensive prognostic stratification model was developed to predict survival and stratify patients for prospective clinical trials. |
format | Text |
id | pubmed-2615339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-26153392009-02-02 A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma Cho, Kang Su Choi, Young Deuk Kim, Se Joong Kim, Chun Il Chung, Byung Ha Seong, Do Hwan Lee, Dong Hyeon Cho, Jin Seon Cho, In Rae Hong, Sung Joon Yonsei Med J Original Article PURPOSE: To develop a reliable prognostic model for patients with metastatic renal cell carcinoma (RCC) based on features readily available in common clinical settings. PATIENTS AND METHODS: A total of 197 patients with RCC who underwent nephrectomy and immunotherapy from 1995 to 2004 were retrospectively reviewed. Their mean age was 55.1 ± 11.8 yrs (24 - 83 yrs) and mean survival time from metastasis was 22.6 ± 20.2 mos (3 - 120 mos). The impact of 24 clinicopathological features on disease specific survival was investigated. RESULTS: On univariate analysis, constitutional symptoms, sarcomatoid differentiation, tumor necrosis, multiple primary lesions, liver metastasis, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), thrombocytosis, alkaline phosphatase, hematocrit, T stage, N stage, and nuclear grade had significant influence on survival (p < 0.05). Multivariate analysis revealed the following features associated with survival: sarcomatoid differentiation [hazard ratio (HR) = 2.99, p < 0.001], liver metastasis (HR = 2.09, p = 0.002), ECOG-PS (HR = 1.95, p = 0.005), N stage (HR = 1.94, p = 0.002), and number of metastatic sites (HR = 1.76, p = 0.003). An individual prognostic score was defined as the sum of the weight of these features. According to prognostic scores, patients could be subdivided into 3 groups: low risk (score 0), intermediate risk (score 1 or 2), and high risk (score ≥ 3). CONCLUSION: A comprehensive prognostic stratification model was developed to predict survival and stratify patients for prospective clinical trials. Yonsei University College of Medicine 2008-06-30 2008-06-20 /pmc/articles/PMC2615339/ /pubmed/18581596 http://dx.doi.org/10.3349/ymj.2008.49.3.451 Text en Copyright © 2008 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cho, Kang Su Choi, Young Deuk Kim, Se Joong Kim, Chun Il Chung, Byung Ha Seong, Do Hwan Lee, Dong Hyeon Cho, Jin Seon Cho, In Rae Hong, Sung Joon A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma |
title | A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma |
title_full | A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma |
title_fullStr | A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma |
title_full_unstemmed | A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma |
title_short | A Comprehensive Prognostic Stratification for Patients with Metastatic Renal Clear Cell Carcinoma |
title_sort | comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615339/ https://www.ncbi.nlm.nih.gov/pubmed/18581596 http://dx.doi.org/10.3349/ymj.2008.49.3.451 |
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