Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication

BACKGROUND: HIV-1 integrase (IN) is a key viral enzymatic molecule required for the integration of the viral cDNA into the genome. Additionally, HIV-1 IN has been shown to play important roles in several other steps during the viral life cycle, including reverse transcription, nuclear import and chr...

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Autores principales: Xu, Zaikun, Zheng, Yingfeng, Ao, Zhujun, Clement, Martin, Mouland, Andrew J, Kalpana, Ganjam V, Belhumeur, Pierre, Cohen, Éric A, Yao, XiaoJian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615443/
https://www.ncbi.nlm.nih.gov/pubmed/19014595
http://dx.doi.org/10.1186/1742-4690-5-102

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