Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes

The cytotoxin colicin E3 targets the 30S subunit of bacterial ribosomes and specifically cleaves 16S rRNA at the decoding centre, thereby inhibiting translation. Although the cleavage site is well known, it is not clear which step of translation is inhibited. We studied the effects of colicin E3 cle...

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Detalles Bibliográficos
Autores principales: Lancaster, Lorna E, Savelsbergh, Andreas, Kleanthous, Colin, Wintermeyer, Wolfgang, Rodnina, Marina V
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615495/
https://www.ncbi.nlm.nih.gov/pubmed/18485067
http://dx.doi.org/10.1111/j.1365-2958.2008.06283.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615495/
https://www.ncbi.nlm.nih.gov/pubmed/18485067
http://dx.doi.org/10.1111/j.1365-2958.2008.06283.x

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