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Multiple Anaphase-promoting Complex/Cyclosome Degrons Mediate the Degradation of Human Sgo1

Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion in early mitosis and, thus, prevents premature sister-chromatid separation. The protein level of Sgo1 is regulated during the cell cycle; it peaks in mitosis and is down-regulated in G(1)/S. Here we show that Sgo1 is degraded during t...

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Detalles Bibliográficos
Autores principales:	Karamysheva, Zemfira, Diaz-Martinez, Laura A., Crow, Sara E., Li, Bing, Yu, Hongtao
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615523/ https://www.ncbi.nlm.nih.gov/pubmed/19015261 http://dx.doi.org/10.1074/jbc.M807083200

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