Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and PPi. Although dUTP is a normal intermediate in DNA synthesis, its accumulation and misincorporation into DNA is lethal. Importantly, uracil misincorporation is a mechanism of cytotoxicity induced by...

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Detalles Bibliográficos
Autores principales: Wilson, Peter M., Fazzone, William, LaBonte, Melissa J., Lenz, Heinz-Josef, Ladner, Robert D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615606/
https://www.ncbi.nlm.nih.gov/pubmed/19015155
http://dx.doi.org/10.1093/nar/gkn910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615606/
https://www.ncbi.nlm.nih.gov/pubmed/19015155
http://dx.doi.org/10.1093/nar/gkn910

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