Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

Regulatory influence of the G-quadruplex or G4 motif present within the nuclease hypersensitive element (NHE) in the promoter of c-MYC has been noted. On the other hand, association of NM23-H2 to the NHE leads to c-MYC activation. Therefore, NM23-H2 interaction with the G4 motif within the c-MYC NHE...

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Detalles Bibliográficos
Autores principales: Thakur, Ram Krishna, Kumar, Praveen, Halder, Kangkan, Verma, Anjali, Kar, Anirban, Parent, Jean-Luc, Basundra, Richa, Kumar, Akinchan, Chowdhury, Shantanu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615625/
https://www.ncbi.nlm.nih.gov/pubmed/19033359
http://dx.doi.org/10.1093/nar/gkn919

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