Potent inhibition of microRNA in vivo without degradation

Chemically modified antisense oligonucleotides (ASOs) are widely used as a tool to functionalize microRNAs (miRNAs). Reduction of miRNA level after ASO inhibition is commonly reported to show efficacy. Whether this is the most relevant endpoint for measuring miRNA inhibition has not been adequately...

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Detalles Bibliográficos
Autores principales: Davis, Scott, Propp, Stephanie, Freier, Susan M., Jones, Laura E., Serra, Martin J., Kinberger, Garth, Bhat, Balkrishen, Swayze, Eric E., Bennett, C. Frank, Esau, Christine
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615630/
https://www.ncbi.nlm.nih.gov/pubmed/19015151
http://dx.doi.org/10.1093/nar/gkn904

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