T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression

Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligand-independent signaling by the precursors of matur...

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Detalles Bibliográficos
Autores principales: Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, Brown, Patrick O, Weiss, Arthur
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC261890/
https://www.ncbi.nlm.nih.gov/pubmed/14624253
http://dx.doi.org/10.1371/journal.pbio.0000053

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