Cargando…

Role of TNF-α in vascular dysfunction

Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) and EDHF (endothelium-dependent hyperpolarizing factor). Vascular dysfunction or injury induced by aging, smoking, inflammation,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hanrui, Park, Yoonjung, Wu, Junxi, Chen, Xiu ping, Lee, Sewon, Yang, Jiyeon, Dellsperger, Kevin C., Zhang, Cuihua
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2620341/
https://www.ncbi.nlm.nih.gov/pubmed/19118493
http://dx.doi.org/10.1042/CS20080196
_version_ 1782163367973093376
author Zhang, Hanrui
Park, Yoonjung
Wu, Junxi
Chen, Xiu ping
Lee, Sewon
Yang, Jiyeon
Dellsperger, Kevin C.
Zhang, Cuihua
author_facet Zhang, Hanrui
Park, Yoonjung
Wu, Junxi
Chen, Xiu ping
Lee, Sewon
Yang, Jiyeon
Dellsperger, Kevin C.
Zhang, Cuihua
author_sort Zhang, Hanrui
collection PubMed
description Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) and EDHF (endothelium-dependent hyperpolarizing factor). Vascular dysfunction or injury induced by aging, smoking, inflammation, trauma, hyperlipidaemia and hyperglycaemia are among a myriad of risk factors that may contribute to the pathogenesis of many cardiovascular diseases, such as hypertension, diabetes and atherosclerosis. However, the exact mechanisms underlying the impaired vascular activity remain unresolved and there is no current scientific consensus. Accumulating evidence suggests that the inflammatory cytokine TNF (tumour necrosis factor)-α plays a pivotal role in the disruption of macrovascular and microvascular circulation both in vivo and in vitro. AGEs (advanced glycation end-products)/RAGE (receptor for AGEs), LOX-1 [lectin-like oxidized low-density lipoprotein receptor-1) and NF-κB (nuclear factor κB) signalling play key roles in TNF-α expression through an increase in circulating and/or local vascular TNF-α production. The increase in TNF-α expression induces the production of ROS (reactive oxygen species), resulting in endothelial dysfunction in many pathophysiological conditions. Lipid metabolism, dietary supplements and physical activity affect TNF-α expression. The interaction between TNF-α and stem cells is also important in terms of vascular repair or regeneration. Careful scrutiny of these factors may help elucidate the mechanisms that induce vascular dysfunction. The focus of the present review is to summarize recent evidence showing the role of TNF-α in vascular dysfunction in cardiovascular disease. We believe these findings may prompt new directions for targeting inflammation in future therapies.
format Text
id pubmed-2620341
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-26203412009-01-13 Role of TNF-α in vascular dysfunction Zhang, Hanrui Park, Yoonjung Wu, Junxi Chen, Xiu ping Lee, Sewon Yang, Jiyeon Dellsperger, Kevin C. Zhang, Cuihua Clin Sci (Lond) Review Article Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) and EDHF (endothelium-dependent hyperpolarizing factor). Vascular dysfunction or injury induced by aging, smoking, inflammation, trauma, hyperlipidaemia and hyperglycaemia are among a myriad of risk factors that may contribute to the pathogenesis of many cardiovascular diseases, such as hypertension, diabetes and atherosclerosis. However, the exact mechanisms underlying the impaired vascular activity remain unresolved and there is no current scientific consensus. Accumulating evidence suggests that the inflammatory cytokine TNF (tumour necrosis factor)-α plays a pivotal role in the disruption of macrovascular and microvascular circulation both in vivo and in vitro. AGEs (advanced glycation end-products)/RAGE (receptor for AGEs), LOX-1 [lectin-like oxidized low-density lipoprotein receptor-1) and NF-κB (nuclear factor κB) signalling play key roles in TNF-α expression through an increase in circulating and/or local vascular TNF-α production. The increase in TNF-α expression induces the production of ROS (reactive oxygen species), resulting in endothelial dysfunction in many pathophysiological conditions. Lipid metabolism, dietary supplements and physical activity affect TNF-α expression. The interaction between TNF-α and stem cells is also important in terms of vascular repair or regeneration. Careful scrutiny of these factors may help elucidate the mechanisms that induce vascular dysfunction. The focus of the present review is to summarize recent evidence showing the role of TNF-α in vascular dysfunction in cardiovascular disease. We believe these findings may prompt new directions for targeting inflammation in future therapies. Portland Press Ltd. 2009-01-08 2009-02-01 /pmc/articles/PMC2620341/ /pubmed/19118493 http://dx.doi.org/10.1042/CS20080196 Text en © 2009 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Hanrui
Park, Yoonjung
Wu, Junxi
Chen, Xiu ping
Lee, Sewon
Yang, Jiyeon
Dellsperger, Kevin C.
Zhang, Cuihua
Role of TNF-α in vascular dysfunction
title Role of TNF-α in vascular dysfunction
title_full Role of TNF-α in vascular dysfunction
title_fullStr Role of TNF-α in vascular dysfunction
title_full_unstemmed Role of TNF-α in vascular dysfunction
title_short Role of TNF-α in vascular dysfunction
title_sort role of tnf-α in vascular dysfunction
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2620341/
https://www.ncbi.nlm.nih.gov/pubmed/19118493
http://dx.doi.org/10.1042/CS20080196
work_keys_str_mv AT zhanghanrui roleoftnfainvasculardysfunction
AT parkyoonjung roleoftnfainvasculardysfunction
AT wujunxi roleoftnfainvasculardysfunction
AT chenxiuping roleoftnfainvasculardysfunction
AT leesewon roleoftnfainvasculardysfunction
AT yangjiyeon roleoftnfainvasculardysfunction
AT dellspergerkevinc roleoftnfainvasculardysfunction
AT zhangcuihua roleoftnfainvasculardysfunction